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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1989-6-6
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pubmed:abstractText |
Pavlovian conditioning of the nudibranch mollusc Hermissenda crassicornis was previously shown to produce long-lasting reduction of two K+ currents measured across the Type B photoreceptor soma membrane (Alkon et al., 1982a; Alkon et al., 1985). Pavlovian conditioning of the rabbit was also shown to be followed by persistent K+ current reduction (Disterhoft et al., 1986). Here we report the first evidence that Ca2+ currents can also be modified by conditioning. The amplitude of the currents rather than their voltage-dependence remains reduced at least 1-2 d after conditioning (but not control procedures). Conditioning-induced changes of both K+ and Ca2+ currents increased as a function of training, the Ca2+ currents only changing substantially with greater than or equal to 250 trials. The later changes of the Ca2+ current may function to limit the magnitude of excitability increases due to associative learning.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2853980-2427133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2853980-3458232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2853980-3491632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2853980-3711982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2853980-3790201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2853980-4062781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2853980-4092073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2853980-6093258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2853980-6112958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2853980-6289442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2853980-6320042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2853980-6498273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2853980-7058334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2853980-7183338
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-3495
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
955-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1988
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pubmed:articleTitle |
Sequential modification of membrane currents with classical conditioning.
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pubmed:affiliation |
Section on Neural Systems, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article,
In Vitro
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