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pubmed-article:2748817pubmed:abstractTextMagnetic resonance (MR) imaging studies of 47 children without thymic disease were compared with those of 14 children with proved thymic abnormalities (eg, lymphoma, leukemia, hyperplasia) to evaluate the spectrum of MR features of the normal and abnormal thymus and to determine the best indicators of thymic disease. In healthy children younger than 5 years of age, the thymus had a quadrilateral shape and biconvex lateral contours. Older children and adolescents had a triangular thymus with straight lateral margins. The thymus appeared homogeneous with a signal intensity slightly greater than that of muscle on T1-weighted images and close to that of fat on T2-weighted images. Qualitative evaluation of gross thymic morphology (size, shape, margins, and signal intensity) usually was sufficient for distinguishing between the normal and abnormal thymus. The abnormal thymus generally was enlarged, multilobular, or inhomogeneous because of the presence of cystic degeneration, hemorrhage, septations, fibrosis, or calcification on pathologic sections. In patients with lymphoma, the presence of associated lymphadenopathy also was helpful in distinguishing the normal from the abnormal thymus.lld:pubmed
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pubmed-article:2748817pubmed:authorpubmed-author:SiegelM JMJlld:pubmed
pubmed-article:2748817pubmed:authorpubmed-author:GlazerH SHSlld:pubmed
pubmed-article:2748817pubmed:authorpubmed-author:MolinaP LPLlld:pubmed
pubmed-article:2748817pubmed:authorpubmed-author:WienerJ IJIlld:pubmed
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pubmed-article:2748817pubmed:pagination367-71lld:pubmed
pubmed-article:2748817pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:2748817pubmed:year1989lld:pubmed
pubmed-article:2748817pubmed:articleTitleNormal and abnormal thymus in childhood: MR imaging.lld:pubmed
pubmed-article:2748817pubmed:affiliationMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110.lld:pubmed
pubmed-article:2748817pubmed:publicationTypeJournal Articlelld:pubmed
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