Linked Life Data

2696722

Source:http://linkedlifedata.com/resource/pubmed/id/2696722

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-4-6
pubmed:abstractText
The Rifamdine (RFD) resistant strains were obtained from wild types of S. aureus NCTC 6571, E. coli NCTC 10418 and Proteus vulgaris by drug concentration gradient plate. The experiment indicated that the growth inhibition of resistant cells induced by synergism of EDTA acting with RFD. Such results did not occur effectively if EDTA or RFD was added separately. The amount of 3H-RFD incorporated into cells of susceptible and resistant strains of E. coli and S. aureus was compared. The amount of 3H-RFD incorporated into susceptible cells was much greater than that of the resistant strains in E. coli cells. Ultrastructure comparison of sensitive and resistant cells showed that the surface of resistant cells was coarser and shorter, the outer membrane thickened and electron density increased. These results have shown that there is a close relationship between the resistance of bacteria induced by RFD and the decrease in the permeability of cell envelope barrier to the drug.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0257-7712
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
[Relationship between bacterial envelope barrier and resistance of E. coli, S. aureus to rifamdine].
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't