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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1990-1-25
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pubmed:abstractText |
The noncompetitive antiestrogenic effects of RU 486 were examined using estradiol (E2)-treated ovariectomized monkeys given RU 486, progesterone (P), or both. The E2-induced luteinizing-hormone (LH) surge of control animals was abrogated by P and/or RU 486. Secretory transformation by P was inhibited by RU 486 coadministration. RU 486 alone (1 mg/kg) induced endometrial secretory transformation, but higher doses (5 mg/kg) inhibited proliferation and secretory activity. Thus in the presence of P, RU 486 is antagonistic but, in absence of P, exhibits endometrial progestational effects at low doses and an antiproliferative (antiestrogenic) effect at higher doses. These data encourage continued evaluation of RU 486 as a potential contraceptive agent acting at the pituitary and/or endometrial level.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Luteinizing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Mifepristone,
http://linkedlifedata.com/resource/pubmed/chemical/Progesterone
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0015-0282
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1055-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2591563-Animals,
pubmed-meshheading:2591563-Dose-Response Relationship, Drug,
pubmed-meshheading:2591563-Endometrium,
pubmed-meshheading:2591563-Estradiol,
pubmed-meshheading:2591563-Estrogen Antagonists,
pubmed-meshheading:2591563-Female,
pubmed-meshheading:2591563-Luteinizing Hormone,
pubmed-meshheading:2591563-Macaca fascicularis,
pubmed-meshheading:2591563-Menstrual Cycle,
pubmed-meshheading:2591563-Mifepristone,
pubmed-meshheading:2591563-Ovariectomy,
pubmed-meshheading:2591563-Progesterone
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pubmed:year |
1989
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pubmed:articleTitle |
Noncompetitive antiestrogenic effect of RU 486 in blocking the estrogen-stimulated luteinizing hormone surge and the proliferative action of estradiol on endometrium in castrate monkeys.
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pubmed:affiliation |
Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, 23510.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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