Linked Life Data

2537132

Source:http://linkedlifedata.com/resource/pubmed/id/2537132

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-4-4
pubmed:abstractText
Mandibular condyles of late embryonic NMRI mice were used in an in vitro organ culture system to study the effect of bone tumor-derived murine leukemia viruses OS-5 MuLV and OA MuLV known to induce osteopetrosis and osteomas. Skeletal precursor cells present in the condylar tissue normally undergo rapid differentiation in vitro which results in new bone formation. The infection of condyles with either OS-5 MuLV or OA MuLV markedly interfered with the normal developmental pattern of the organ leading to the formation of an atypical, heavily mineralized tissue. Many spindlelike cells and pleomorphic cells were encountered, whereas fibroblastlike cells were found to penetrate an underlying collagen substratum. These observations indicate that bone tumor-inducing leukemogenic retroviruses directly affect cartilage and/or bone precursor cells resulting in pathologic developments in the skeleton.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0171-967X
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Effects of leukemogenic retroviruses on condylar cartilage in vitro: an ultrastructural study.
pubmed:affiliation
Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't