| pubmed-article:2499461 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2499461 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2499461 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:2499461 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:2499461 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:2499461 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:2499461 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2499461 | pubmed:dateCreated | 1989-7-27 | lld:pubmed |
| pubmed-article:2499461 | pubmed:abstractText | Monocytes of seven out of eight patients with type 1 C1-inhibitor (C1-inh) deficiency (HAE) produced 40% as much C1-inh as monocytes from normal donors (controls). In contrast, monocytes from three patients with type 2 and three patients with acquired C1-inh deficiency produced similar amounts of C1-inh as controls. Recombinant gamma-interferon (gamma-interferon 10 ng/ml) stimulated C1-inh production of C1-inh (eight-10-fold) by control and patients' monocytes. Monocytes from patients with type 1 HAE contained 40% the level of C1-inh messenger ribonucleic acid (mRNA) found in control monocytes. Gamma-interferon increased the abundance of C1-inh mRNA by the same extent in both control and patients' monocytes. C1-inh protein and mRNA were undetectable in the monocytes of one patient, unless stimulated by gamma-interferon. Under these conditions, his monocytes produced comparable amounts of C1-inh (protein and mRNA) as gamma-interferon-stimulated monocytes of the other type 1 HAE patients. The data suggest that in most type 2 HAE patients there is a lesion in the C1-inh gene such that mRNA is transcribed by a single allele. | lld:pubmed |
| pubmed-article:2499461 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2499461 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2499461 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2499461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2499461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2499461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2499461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2499461 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2499461 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2499461 | pubmed:issn | 0014-2972 | lld:pubmed |
| pubmed-article:2499461 | pubmed:author | pubmed-author:WhaleyKK | lld:pubmed |
| pubmed-article:2499461 | pubmed:author | pubmed-author:YamP APA | lld:pubmed |
| pubmed-article:2499461 | pubmed:author | pubmed-author:BirnieG DGD | lld:pubmed |
| pubmed-article:2499461 | pubmed:author | pubmed-author:FothergillJ... | lld:pubmed |
| pubmed-article:2499461 | pubmed:author | pubmed-author:CarterP EPE | lld:pubmed |
| pubmed-article:2499461 | pubmed:author | pubmed-author:McPhadenA RAR | lld:pubmed |
| pubmed-article:2499461 | pubmed:author | pubmed-author:LappinD FDF | lld:pubmed |
| pubmed-article:2499461 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2499461 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:2499461 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2499461 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2499461 | pubmed:pagination | 45-52 | lld:pubmed |
| pubmed-article:2499461 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:2499461 | pubmed:meshHeading | pubmed-meshheading:2499461-... | lld:pubmed |
| pubmed-article:2499461 | pubmed:meshHeading | pubmed-meshheading:2499461-... | lld:pubmed |
| pubmed-article:2499461 | pubmed:meshHeading | pubmed-meshheading:2499461-... | lld:pubmed |
| pubmed-article:2499461 | pubmed:meshHeading | pubmed-meshheading:2499461-... | lld:pubmed |
| pubmed-article:2499461 | pubmed:meshHeading | pubmed-meshheading:2499461-... | lld:pubmed |
| pubmed-article:2499461 | pubmed:meshHeading | pubmed-meshheading:2499461-... | lld:pubmed |
| pubmed-article:2499461 | pubmed:meshHeading | pubmed-meshheading:2499461-... | lld:pubmed |
| pubmed-article:2499461 | pubmed:meshHeading | pubmed-meshheading:2499461-... | lld:pubmed |
| pubmed-article:2499461 | pubmed:meshHeading | pubmed-meshheading:2499461-... | lld:pubmed |
| pubmed-article:2499461 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2499461 | pubmed:articleTitle | Monocyte C1-inhibitor synthesis in patients with C1-inhibitor deficiency. | lld:pubmed |
| pubmed-article:2499461 | pubmed:affiliation | University of Glasgow Pathology Department, Western Infirmary, Scotland, U.K. | lld:pubmed |
| pubmed-article:2499461 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2499461 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2499461 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2499461 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2499461 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2499461 | lld:pubmed |
