| pubmed-article:2175724 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2175724 | lifeskim:mentions | umls-concept:C1882857 | lld:lifeskim |
| pubmed-article:2175724 | lifeskim:mentions | umls-concept:C0037657 | lld:lifeskim |
| pubmed-article:2175724 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:2175724 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:2175724 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:2175724 | pubmed:dateCreated | 1991-2-7 | lld:pubmed |
| pubmed-article:2175724 | pubmed:abstractText | To determine if insulin-like growth factor-I (IGF-I) or multiplication stimulating activity (MSA, rat IGF-II) might directly influence small intestinal epithelium, we studied the distribution of IGF binding sites during development of the rat intestine. Cell membranes from suckling rat mucosa bound 2-6 times as much 125I-IGF-I and 3-5 times as much 125I-MSA as did adult membranes. Isolated villus cells from suckling and adult rats specifically bound both IGFs. IGF-I binding tended to remain high during suckling, whereas MSA binding fell progressively from the early suckling period. Competitive displacement studies with insulin, IGF-I and MSA demonstrated the presence of type-I and type-II IGF receptors. In vitro autoradiography of 125I-IGF-I binding sites in adult and suckling rat jejunum showed highest binding in the submucosa with extensions up into the lamina propria. Immunocytochemical localization of type-II receptors showed highest density in villus epithelium and vessel walls. Administration of MSA by oral and IGF-I by oral and parenteral routes (1 microgram/day for 6 days) to suckling rats stimulated jejunal brush border enzymes, but not intestinal growth. Developmental changes in receptor density and effects on brush border enzymes suggest a specific role for IGFs in post-natal development of the rat intestine. | lld:pubmed |
| pubmed-article:2175724 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2175724 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2175724 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2175724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2175724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2175724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2175724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2175724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2175724 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2175724 | pubmed:issn | 0012-2823 | lld:pubmed |
| pubmed-article:2175724 | pubmed:author | pubmed-author:CoxA JAJ | lld:pubmed |
| pubmed-article:2175724 | pubmed:author | pubmed-author:HoggAA | lld:pubmed |
| pubmed-article:2175724 | pubmed:author | pubmed-author:YoungG PGP | lld:pubmed |
| pubmed-article:2175724 | pubmed:author | pubmed-author:WertherG AGA | lld:pubmed |
| pubmed-article:2175724 | pubmed:author | pubmed-author:JonasH AHA | lld:pubmed |
| pubmed-article:2175724 | pubmed:author | pubmed-author:TarantoT MTM | lld:pubmed |
| pubmed-article:2175724 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2175724 | pubmed:volume | 46 Suppl 2 | lld:pubmed |
| pubmed-article:2175724 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2175724 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2175724 | pubmed:pagination | 240-52 | lld:pubmed |
| pubmed-article:2175724 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2175724 | pubmed:meshHeading | pubmed-meshheading:2175724-... | lld:pubmed |
| pubmed-article:2175724 | pubmed:meshHeading | pubmed-meshheading:2175724-... | lld:pubmed |
| pubmed-article:2175724 | pubmed:meshHeading | pubmed-meshheading:2175724-... | lld:pubmed |
| pubmed-article:2175724 | pubmed:meshHeading | pubmed-meshheading:2175724-... | lld:pubmed |
| pubmed-article:2175724 | pubmed:meshHeading | pubmed-meshheading:2175724-... | lld:pubmed |
| pubmed-article:2175724 | pubmed:meshHeading | pubmed-meshheading:2175724-... | lld:pubmed |
| pubmed-article:2175724 | pubmed:meshHeading | pubmed-meshheading:2175724-... | lld:pubmed |
| pubmed-article:2175724 | pubmed:meshHeading | pubmed-meshheading:2175724-... | lld:pubmed |
| pubmed-article:2175724 | pubmed:meshHeading | pubmed-meshheading:2175724-... | lld:pubmed |
| pubmed-article:2175724 | pubmed:meshHeading | pubmed-meshheading:2175724-... | lld:pubmed |
| pubmed-article:2175724 | pubmed:meshHeading | pubmed-meshheading:2175724-... | lld:pubmed |
| pubmed-article:2175724 | pubmed:meshHeading | pubmed-meshheading:2175724-... | lld:pubmed |
| pubmed-article:2175724 | pubmed:meshHeading | pubmed-meshheading:2175724-... | lld:pubmed |
| pubmed-article:2175724 | pubmed:meshHeading | pubmed-meshheading:2175724-... | lld:pubmed |
| pubmed-article:2175724 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2175724 | pubmed:articleTitle | Insulin-like growth factors and the developing and mature rat small intestine: receptors and biological actions. | lld:pubmed |
| pubmed-article:2175724 | pubmed:affiliation | University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Vic., Australia. | lld:pubmed |
| pubmed-article:2175724 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2175724 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2175724 | lld:pubmed |
