Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-7-12
pubmed:abstractText
Mesial temporal lobe epilepsy (MTLE) is the most common medically refractory epilepsy syndrome in adults, and hippocampal sclerosis (HS) is the most frequently encountered lesion in patients with MTLE. Premature accumulation of corpora amylacea (CoA), which plays an important role in the sequestration of toxic cellular metabolites, is found in the hippocampus of 50-60% of the patients who undergo surgery for medically refractory MTLE-HS. However, the etiopathogenesis and clinical importance of this phenomenon are still uncertain. The ABCB1 gene product P-glycoprotein (P-gp) plays a prominent role as an antiapoptotic factor in addition to its efflux transporter function. ABCB1 polymorphism has been found to be associated with downregulation of P-gp expression. We hypothesized that a similar polymorphism will be found in patients with CoA deposition, as the polymorphism predisposes the hippocampal neuronal and glial cells to seizure-induced excitotoxic damage and CoA formation ensues as a buffer response.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-10209236, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-10637601, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-10963475, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-12122045, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-12152989, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-12686700, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-12916020, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-14685825, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-15144438, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-15505619, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-16025095, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-16190932, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-17336043, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-17392402, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-17460550, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-18791064, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-19178561, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-19325113, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-19455183, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-19889013, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-20605481, http://linkedlifedata.com/resource/pubmed/commentcorrection/21747587-8001500
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
May
pubmed:issn
0971-6866
pubmed:author
pubmed:issnType
Print
pubmed:volume
17 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S41-7
pubmed:dateRevised
2011-8-1
pubmed:year
2011
pubmed:articleTitle
Corpora amylacea deposition in the hippocampus of patients with mesial temporal lobe epilepsy: A new role for an old gene?
pubmed:affiliation
R. Madhavan Nayar Center for Comprehensive Epilepsy Care, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.
pubmed:publicationType
Journal Article