Linked Life Data

21710495

Source:http://linkedlifedata.com/resource/pubmed/id/21710495

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-6-28
pubmed:abstractText
We previously showed that exposure to UV radiation after immunization suppresses Th1 and Th2 immune responses, leading to impaired Ab and allo-immune responses, but the impact of UV radiation after immunization on anti-tumor immune responses mediated by tumor-specific CD8(+) T cell responses remains less clear. Furthermore, the exact phenotypic and functional characteristics of regulatory T cell population responsible for the UV-induced immunosuppression still remain elusive. Using the MBL-2 lymphoma cell line engineered to express OVA as a surrogate tumor Ag, here we demonstrate that UV irradiation after tumor Ag-immunization suppresses the anti-tumor immune response in a manner dependent on the immunizing Ag. This suppression was mediated by interleukin (IL)-10 released from CD4(+) CD25(+) T cells, by which impaired the induction of cytotoxic T lymphocytes (CTL) able to kill Ag-expressing tumor cells. In addition, we generated a panel of T cell clones from UV-irradiated and non-irradiated mice, and all of the clones derived from UV-irradiated mice had a Tr1-type regulatory T cell phenotype with expression of IL-10 and c-Maf, but not Foxp3. These Tr1-type regulatory T cell clones suppressed tumor rejection in vivo as well as Th cell activation in vitro in an IL-10 dependent manner. Given that suppression of Ag-specific CTL responses can be induced in Ag-sensitized mice by UV irradiation, our results may imply that exposure to UV radiation during premalignant stage induces tumor-Ag specific Tr1 cells that mediate tumor-Ag specific immune suppression resulting in the promotion of tumor progression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1097-0215
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 UICC.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1126-36
pubmed:meshHeading
pubmed-meshheading:21710495-Animals, pubmed-meshheading:21710495-Blotting, Western, pubmed-meshheading:21710495-CD4-Positive T-Lymphocytes, pubmed-meshheading:21710495-CD8-Positive T-Lymphocytes, pubmed-meshheading:21710495-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:21710495-Female, pubmed-meshheading:21710495-Immune Tolerance, pubmed-meshheading:21710495-Immunization, pubmed-meshheading:21710495-Immunosuppression, pubmed-meshheading:21710495-Interleukin-10, pubmed-meshheading:21710495-Lymphocyte Activation, pubmed-meshheading:21710495-Lymphoma, pubmed-meshheading:21710495-Mice, pubmed-meshheading:21710495-Mice, Inbred C57BL, pubmed-meshheading:21710495-Ovalbumin, pubmed-meshheading:21710495-Proto-Oncogene Proteins c-maf, pubmed-meshheading:21710495-RNA, Messenger, pubmed-meshheading:21710495-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:21710495-T-Lymphocytes, Cytotoxic, pubmed-meshheading:21710495-T-Lymphocytes, Regulatory, pubmed-meshheading:21710495-Th1 Cells, pubmed-meshheading:21710495-Th2 Cells, pubmed-meshheading:21710495-Ultraviolet Rays
pubmed:year
2011
pubmed:articleTitle
UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific cytotoxic T lymphocyte responses.
pubmed:affiliation
Department of Cellular and Molecular Immunology, Mie Graduate School of Medicine, Tsu, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't