| pubmed-article:21525190 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21525190 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:21525190 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:21525190 | lifeskim:mentions | umls-concept:C0279626 | lld:lifeskim |
| pubmed-article:21525190 | lifeskim:mentions | umls-concept:C0521449 | lld:lifeskim |
| pubmed-article:21525190 | lifeskim:mentions | umls-concept:C0332397 | lld:lifeskim |
| pubmed-article:21525190 | lifeskim:mentions | umls-concept:C1425059 | lld:lifeskim |
| pubmed-article:21525190 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:21525190 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:21525190 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:21525190 | pubmed:dateCreated | 2011-6-27 | lld:pubmed |
| pubmed-article:21525190 | pubmed:abstractText | The aim of this study was to evaluate HDPR1 expression in esophageal squamous cell carcinoma (ESCC) and the relationship between HDPR1 and beta-catenin by immunohistochemical analysis. The clinical relevance of these proteins was also analyzed. Immunohistochemistry was performed on paraffin-embedded tissue specimens from 184 ESCC patients to detect the expression of HDPR1 and beta-catenin. The correlation between the results of immunoexpression and the clinicopathologic features was processed statistically. Increased cytoplasmic and nuclear HDPR1 expression was noted in 100 (54.3%) and 131 (71.2%) of 184 specimens, respectively. Statistical analysis showed significant associations of cytoplasmic HDPR1 with regional lymph node metastasis (p = 0.021) and P-stage (p = 0.004). The increased nuclear staining was only correlated with P-stage (p = 0.047). Significant associations of coexpression of cytoplasmic and nuclear HDPR1 with regional lymph node metastasis (p = 0.015) or P-stage (p = 0.002) were observed. Enhanced cytoplasmic expression of HDPR1 was positively correlated with increased cytoplasmic but not reduced membranous beta-catenin expression (r = 0.239, p = 0.027 and r = 0.126, p = 0.089, respectively). These finding suggested that cytoplasmic HDPR1 protein expression was associated with tumor malignant progression via beta-catenin accumulation. It implicated that cytoplasmic HDPR1 expression may serve as a potential predictive factor for lymph node metastasis and tumor development in ESCC. | lld:pubmed |
| pubmed-article:21525190 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21525190 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21525190 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21525190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21525190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21525190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21525190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21525190 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21525190 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21525190 | pubmed:issn | 1551-5044 | lld:pubmed |
| pubmed-article:21525190 | pubmed:author | pubmed-author:ShenJianJ | lld:pubmed |
| pubmed-article:21525190 | pubmed:author | pubmed-author:XuLi-YanLY | lld:pubmed |
| pubmed-article:21525190 | pubmed:author | pubmed-author:LiEn-MinEM | lld:pubmed |
| pubmed-article:21525190 | pubmed:author | pubmed-author:HouJianJ | lld:pubmed |
| pubmed-article:21525190 | pubmed:author | pubmed-author:WuZhi-YongZY | lld:pubmed |
| pubmed-article:21525190 | pubmed:author | pubmed-author:GuoMing-ZhouM... | lld:pubmed |
| pubmed-article:21525190 | pubmed:author | pubmed-author:ShenJin-HuiJH | lld:pubmed |
| pubmed-article:21525190 | pubmed:author | pubmed-author:WuJian-YiJY | lld:pubmed |
| pubmed-article:21525190 | pubmed:author | pubmed-author:XuXiu-EXE | lld:pubmed |
| pubmed-article:21525190 | pubmed:author | pubmed-author:Qing-Zhao | lld:pubmed |
| pubmed-article:21525190 | pubmed:author | pubmed-author:Qiao-Huang | lld:pubmed |
| pubmed-article:21525190 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21525190 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:21525190 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21525190 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21525190 | pubmed:pagination | 711-8 | lld:pubmed |
| pubmed-article:21525190 | pubmed:dateRevised | 2011-10-27 | lld:pubmed |
| pubmed-article:21525190 | pubmed:meshHeading | pubmed-meshheading:21525190... | lld:pubmed |
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| pubmed-article:21525190 | pubmed:meshHeading | pubmed-meshheading:21525190... | lld:pubmed |
| pubmed-article:21525190 | pubmed:meshHeading | pubmed-meshheading:21525190... | lld:pubmed |
| pubmed-article:21525190 | pubmed:meshHeading | pubmed-meshheading:21525190... | lld:pubmed |
| pubmed-article:21525190 | pubmed:meshHeading | pubmed-meshheading:21525190... | lld:pubmed |
| pubmed-article:21525190 | pubmed:meshHeading | pubmed-meshheading:21525190... | lld:pubmed |
| pubmed-article:21525190 | pubmed:meshHeading | pubmed-meshheading:21525190... | lld:pubmed |
| pubmed-article:21525190 | pubmed:meshHeading | pubmed-meshheading:21525190... | lld:pubmed |
| pubmed-article:21525190 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21525190 | pubmed:articleTitle | Cytoplasmic HDPR1 is involved in regional lymph node metastasis and tumor development via beta-catenin accumulation in esophageal squamous cell carcinoma. | lld:pubmed |
| pubmed-article:21525190 | pubmed:affiliation | Institute of Oncologic Pathology, Medical College of Shantou University, Shantou, Guangdong, China. | lld:pubmed |
| pubmed-article:21525190 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21525190 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:51339 | entrezgene:pubmed | pubmed-article:21525190 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21525190 | lld:entrezgene |
