Source:http://linkedlifedata.com/resource/pubmed/id/21525190
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2011-6-27
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| pubmed:abstractText |
The aim of this study was to evaluate HDPR1 expression in esophageal squamous cell carcinoma (ESCC) and the relationship between HDPR1 and beta-catenin by immunohistochemical analysis. The clinical relevance of these proteins was also analyzed. Immunohistochemistry was performed on paraffin-embedded tissue specimens from 184 ESCC patients to detect the expression of HDPR1 and beta-catenin. The correlation between the results of immunoexpression and the clinicopathologic features was processed statistically. Increased cytoplasmic and nuclear HDPR1 expression was noted in 100 (54.3%) and 131 (71.2%) of 184 specimens, respectively. Statistical analysis showed significant associations of cytoplasmic HDPR1 with regional lymph node metastasis (p = 0.021) and P-stage (p = 0.004). The increased nuclear staining was only correlated with P-stage (p = 0.047). Significant associations of coexpression of cytoplasmic and nuclear HDPR1 with regional lymph node metastasis (p = 0.015) or P-stage (p = 0.002) were observed. Enhanced cytoplasmic expression of HDPR1 was positively correlated with increased cytoplasmic but not reduced membranous beta-catenin expression (r = 0.239, p = 0.027 and r = 0.126, p = 0.089, respectively). These finding suggested that cytoplasmic HDPR1 protein expression was associated with tumor malignant progression via beta-catenin accumulation. It implicated that cytoplasmic HDPR1 expression may serve as a potential predictive factor for lymph node metastasis and tumor development in ESCC.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
|
| pubmed:issn |
1551-5044
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
59
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
711-8
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| pubmed:dateRevised |
2011-10-27
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| pubmed:meshHeading |
pubmed-meshheading:21525190-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:21525190-Adult,
pubmed-meshheading:21525190-Aged,
pubmed-meshheading:21525190-Aged, 80 and over,
pubmed-meshheading:21525190-Carcinoma, Squamous Cell,
pubmed-meshheading:21525190-Cytoplasm,
pubmed-meshheading:21525190-Esophageal Neoplasms,
pubmed-meshheading:21525190-Female,
pubmed-meshheading:21525190-Humans,
pubmed-meshheading:21525190-Kaplan-Meier Estimate,
pubmed-meshheading:21525190-Lymph Nodes,
pubmed-meshheading:21525190-Lymphatic Metastasis,
pubmed-meshheading:21525190-Male,
pubmed-meshheading:21525190-Middle Aged,
pubmed-meshheading:21525190-Nuclear Proteins,
pubmed-meshheading:21525190-Retrospective Studies,
pubmed-meshheading:21525190-Survival Rate,
pubmed-meshheading:21525190-beta Catenin
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Cytoplasmic HDPR1 is involved in regional lymph node metastasis and tumor development via beta-catenin accumulation in esophageal squamous cell carcinoma.
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| pubmed:affiliation |
Institute of Oncologic Pathology, Medical College of Shantou University, Shantou, Guangdong, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|