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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-2-14
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pubmed:abstractText |
Pentagalloylglucose (PGG) is a natural polyphenolic compound with broad-spectrum anti-viral activity, however, the mechanisms underlying anti-viral activity remain undefined. In this study, we investigated the effects of PGG on anti-viral activity against Herpes simplex virus type 1 (HSV-1) associated with autophagy. We found that the PGG anti-HSV-1 activity was impaired significantly in MEF-atg7-/- cells (autophagy-defective cells) derived from an atg7-/- knockout mouse. Transmission electron microscopy revealed that PGG-induced autophagosomes engulfed HSV-1 virions. The mTOR signaling pathway, an essential pathway for the regulation of autophagy, was found to be suppressed following PGG treatment. Data presented in this report demonstrated for the first time that autophagy induced following PGG treatment contributed to its anti-HSV activity in vitro.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1090-2104
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pubmed:author |
pubmed-author:ChenZhen-PingZP,
pubmed-author:FähLL,
pubmed-author:GuoChao-wanCW,
pubmed-author:JiYu-huaYH,
pubmed-author:JuHuai-QiangHQ,
pubmed-author:KitazatoKaioK,
pubmed-author:KomatsuMasaakiM,
pubmed-author:PeiYingY,
pubmed-author:WangYi-FeiYF,
pubmed-author:YangChong-RenCR,
pubmed-author:ZhangYing-JunYJ
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
405
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
186-91
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pubmed:meshHeading |
pubmed-meshheading:21216235-Animals,
pubmed-meshheading:21216235-Antiviral Agents,
pubmed-meshheading:21216235-Autophagy,
pubmed-meshheading:21216235-Cell Line,
pubmed-meshheading:21216235-DNA-Binding Proteins,
pubmed-meshheading:21216235-Herpesvirus 1, Human,
pubmed-meshheading:21216235-Humans,
pubmed-meshheading:21216235-Hydrolyzable Tannins,
pubmed-meshheading:21216235-Mice,
pubmed-meshheading:21216235-Mice, Knockout,
pubmed-meshheading:21216235-Microtubule-Associated Proteins,
pubmed-meshheading:21216235-Phagosomes,
pubmed-meshheading:21216235-Transcription Factors
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pubmed:year |
2011
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pubmed:articleTitle |
Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro.
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pubmed:affiliation |
Biomedicine Research and Development Center of Jinan University, Guangzhou, Guangdong 510632, China. peiying-19802@163.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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