Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-31
pubmed:abstractText
Leprosy is a debilitating chronic disease caused by infection with Mycobacterium leprae. A World Health Organization-directed control strategy based upon the identification and treatment of patients has resulted in a marked reduction in the number of registered worldwide leprosy cases over the last 20 years. Despite these efforts, the number of new leprosy cases detected each year now remains relatively stable, and M. leprae infection continues to pose a health problem. It is suggested that earlier diagnosis is required to strengthen control programs. In this study, we have examined the development of antigen-specific immunoglobulin responses within armadillos experimentally infected with M. leprae to identify those responses that develop most rapidly and robustly following infection. Antibody responses to the M. leprae-specific phenolic glycolipid I and several protein antigens previously demonstrated to have diagnostic potential were assessed. Our results identify several antigens that can provide early diagnosis of M. leprae infection but also indicate considerable variability in the development of antigen-specific antibodies. Our data suggest that a combination of antigens is likely required to provide accurate and early leprosy diagnosis.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-10834065, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-11139208, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-11234002, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-11332290, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-11480310, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-12225510, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-12549844, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-12734239, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-14577464, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-14750580, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-15358649, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-16522774, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-16614253, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-17898185, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-17989339, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-18301731, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-18716007, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-18784342, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-18945881, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-19204343, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-20016045, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-20447668, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-3546545, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-4417433, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-4589901, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-592741, http://linkedlifedata.com/resource/pubmed/commentcorrection/21177914-5950347
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1556-679X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
254-9
pubmed:dateRevised
2011-8-3
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Insight toward early diagnosis of leprosy through analysis of the developing antibody responses of Mycobacterium leprae-infected armadillos.
pubmed:affiliation
Infectious Disease Research Institute, 1124 Columbia St., Seattle, WA 98104, USA. mduthie@idri.org
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Evaluation Studies, Research Support, N.I.H., Extramural