rdf:type |
|
lifeskim:mentions |
umls-concept:C0002723,
umls-concept:C0009319,
umls-concept:C0018270,
umls-concept:C0021853,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0221908,
umls-concept:C0521009,
umls-concept:C0871261,
umls-concept:C1517004,
umls-concept:C1533691,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
pubmed:dateCreated |
2010-11-26
|
pubmed:abstractText |
Serum Amyloid A (SAA) is a major acute phase protein of unknown function. SAA is mostly expressed in the liver, but also in other tissues including the intestinal epithelium. SAA reportedly has anti-bacterial effects, and because inflammatory bowel diseases (IBD) result from a breakdown in homeostatic interactions between intestinal epithelia and bacteria, we hypothesized that SAA is protective during experimental colitis.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
1471-230X
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
10
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
133
|
pubmed:dateRevised |
2011-10-21
|
pubmed:meshHeading |
pubmed-meshheading:21067563-Animals,
pubmed-meshheading:21067563-Bacteria,
pubmed-meshheading:21067563-Biopsy,
pubmed-meshheading:21067563-Cell Line,
pubmed-meshheading:21067563-Colitis,
pubmed-meshheading:21067563-DNA,
pubmed-meshheading:21067563-Disease Models, Animal,
pubmed-meshheading:21067563-Disease Progression,
pubmed-meshheading:21067563-Gene Expression Regulation,
pubmed-meshheading:21067563-Humans,
pubmed-meshheading:21067563-Immunoblotting,
pubmed-meshheading:21067563-In Situ Hybridization,
pubmed-meshheading:21067563-Intestinal Mucosa,
pubmed-meshheading:21067563-Mice,
pubmed-meshheading:21067563-Mice, Inbred C57BL,
pubmed-meshheading:21067563-Polymerase Chain Reaction,
pubmed-meshheading:21067563-Serum Amyloid A Protein
|
pubmed:year |
2010
|
pubmed:articleTitle |
Intestinal epithelial serum amyloid A modulates bacterial growth in vitro and pro-inflammatory responses in mouse experimental colitis.
|
pubmed:affiliation |
Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY, USA. erik.eckhardt@uky.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
|