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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-10-15
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pubmed:abstractText |
The intestinal microbiota plays a critical role in maintaining human health; however, the mechanisms governing the normal homeostatic number and composition of these microbes are largely unknown. Previously it was shown that intestinal alkaline phosphatase (IAP), a small intestinal brush border enzyme, functions as a gut mucosal defence factor limiting the translocation of gut bacteria to mesenteric lymph nodes. In this study the role of IAP in the preservation of the normal homeostasis of the gut microbiota was investigated.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1468-3288
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pubmed:author |
pubmed-author:AlamS NasrinSN,
pubmed-author:BiswasBB,
pubmed-author:DICKJ RJR,
pubmed-author:EbrahimiFF,
pubmed-author:FaruquiAA,
pubmed-author:HodinR ARA,
pubmed-author:HodinSS,
pubmed-author:HohmannE LEL,
pubmed-author:JohnsonP VPV,
pubmed-author:KaplanJ BJB,
pubmed-author:KittsC LCL,
pubmed-author:MaloM SMS,
pubmed-author:MaloP SPS,
pubmed-author:MillánJ LJL,
pubmed-author:MohammadNN,
pubmed-author:MostafaGG,
pubmed-author:NarisawaSS,
pubmed-author:ObodP VPV,
pubmed-author:RamasamySS,
pubmed-author:WarnerD WDW,
pubmed-author:ZellerS JSJ
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pubmed:issnType |
Electronic
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1476-84
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pubmed:meshHeading |
pubmed-meshheading:20947883-Administration, Oral,
pubmed-meshheading:20947883-Alkaline Phosphatase,
pubmed-meshheading:20947883-Animals,
pubmed-meshheading:20947883-Escherichia coli,
pubmed-meshheading:20947883-Feces,
pubmed-meshheading:20947883-Gram-Negative Aerobic Bacteria,
pubmed-meshheading:20947883-Gram-Negative Anaerobic Bacteria,
pubmed-meshheading:20947883-Homeostasis,
pubmed-meshheading:20947883-Intestine, Small,
pubmed-meshheading:20947883-Metagenome,
pubmed-meshheading:20947883-Mice,
pubmed-meshheading:20947883-Mice, Inbred C57BL,
pubmed-meshheading:20947883-Mice, Knockout,
pubmed-meshheading:20947883-Phylogeny,
pubmed-meshheading:20947883-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:20947883-RNA, Bacterial,
pubmed-meshheading:20947883-RNA, Ribosomal, 16S,
pubmed-meshheading:20947883-Salmonella typhimurium
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pubmed:year |
2010
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pubmed:articleTitle |
Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota.
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pubmed:affiliation |
Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA. mmalo@partners.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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