Linked Life Data

20890272

Source:http://linkedlifedata.com/resource/pubmed/id/20890272

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-1-4
pubmed:abstractText
The B-cell survival factors APRIL and BLyS are important for B-cell maturation and activation and contribute to human autoimmune diseases. Interference with B-cell function by targeting these molecules is currently being investigated in large clinical trials for systemic lupus erythematosus. The local expression patterns of APRIL and BLyS have not been investigated in detail in kidneys with lupus nephritis. We studied the mRNA expression of APRIL, BLyS, and the corresponding receptors BCMA, TACI, and BAFF-R in microdissected human biopsies with proliferative lupus nephritis (n=25) and compared it with pretransplant biopsies of living donors (n=9). APRIL and BLyS mRNA levels were significantly higher in glomeruli of patients with proliferative lupus nephritis (12- and 30-fold, respectively). Tubulointerstitial expression of APRIL, BLyS, BCMA, and TACI was also significantly elevated. To localize the respective proteins in the kidney, APRIL, BLyS, and BAFF-R were studied by immunohistochemistry in renal biopsies with proliferative (n=21) or membranous (n=8) lupus nephritis. APRIL was prominently expressed in glomeruli with proliferative, but not membranous, lupus nephritis. The staining pattern was consistent with mesangial cells. A prominent accumulation of CD68-positive cells was present in glomeruli in association with APRIL expression. APRIL, BLyS, and BAFF-R were also expressed in interstitial inflammatory cell accumulation. This is the first study, which details local expression of APRIL and BLyS in glomeruli and tubulointerstitium of human proliferative lupus nephritis. This information might help define intrarenal effects of APRIL and BLyS inhibition in human lupus nephritis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1530-0285
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
98-107
pubmed:meshHeading
pubmed-meshheading:20890272-Adolescent, pubmed-meshheading:20890272-Adult, pubmed-meshheading:20890272-Aged, pubmed-meshheading:20890272-B-Cell Activating Factor, pubmed-meshheading:20890272-B-Cell Activation Factor Receptor, pubmed-meshheading:20890272-B-Lymphocytes, pubmed-meshheading:20890272-Cell Survival, pubmed-meshheading:20890272-Female, pubmed-meshheading:20890272-Gene Expression, pubmed-meshheading:20890272-Glomerulonephritis, Membranoproliferative, pubmed-meshheading:20890272-Glomerulonephritis, Membranous, pubmed-meshheading:20890272-Humans, pubmed-meshheading:20890272-Immunohistochemistry, pubmed-meshheading:20890272-Kidney Glomerulus, pubmed-meshheading:20890272-Lupus Nephritis, pubmed-meshheading:20890272-Male, pubmed-meshheading:20890272-Microdissection, pubmed-meshheading:20890272-Middle Aged, pubmed-meshheading:20890272-RNA, Messenger, pubmed-meshheading:20890272-Tumor Necrosis Factor Ligand Superfamily Member 13, pubmed-meshheading:20890272-Young Adult
pubmed:year
2011
pubmed:articleTitle
Intrarenal production of B-cell survival factors in human lupus nephritis.
pubmed:affiliation
Division of Nephrology, Department of Internal Medicine, University Hospital, Zurich, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't