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pubmed-article:20827463pubmed:abstractTextThe h5-HT(7) receptor is subject to inactivation by risperidone and 9-OH-risperidone, apparently through a pseudo-irreversible complex formed between these drugs and the receptor. Although risperidone and 9-OH-risperidone ("inactivating antagonists") completely inactivate the receptor, only 50% of the receptors form a pseudo-irreversible complex with these drugs.lld:pubmed
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pubmed-article:20827463pubmed:articleTitleClozapine and other competitive antagonists reactivate risperidone-inactivated h5-HT7 receptors: radioligand binding and functional evidence for GPCR homodimer protomer interactions.lld:pubmed
pubmed-article:20827463pubmed:affiliationCenter for Neuropharmacology & Neuroscience, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA. teitlem@mail.amc.edulld:pubmed
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