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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2010-8-30
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pubmed:abstractText |
A series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles are reported which were found to be potent and selective muscarinic M1 agonists. By control of the physicochemical characteristics of the series, particularly the lipophilicity, compounds with good metabolic stability and excellent brain penetration were identified. An exemplar of the series was shown to be pro-cognitive in the novel object recognition rat model of temporal induced memory deficit.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BradfordAndrea MAM,
pubmed-author:BrownFionaF,
pubmed-author:FlynnSean TST,
pubmed-author:ForbesIan TIT,
pubmed-author:GartlonJane EJE,
pubmed-author:GarzyaVincenzoV,
pubmed-author:JohnsonDale JDJ,
pubmed-author:LucasAdam JAJ,
pubmed-author:MookherjeeClaudette RCR,
pubmed-author:MudharHarminder SHS,
pubmed-author:MurkittGraham SGS,
pubmed-author:SmithPaul WPW,
pubmed-author:StevensonGraeme IGI,
pubmed-author:TimofeevaA IuAIu,
pubmed-author:WalkerGraham RGR,
pubmed-author:WatsonJeannette MJM,
pubmed-author:WatsonSteve PSP
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pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5434-8
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists.
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pubmed:affiliation |
GlaxoSmithKline, New Frontiers Science Park, 3rd Avenue, Harlow, Essex CM19 5AW, UK. dalejames.johnson@gmail.com
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pubmed:publicationType |
Journal Article
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