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rdf:type |
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lifeskim:mentions |
umls-concept:C0003842,
umls-concept:C0011209,
umls-concept:C0014257,
umls-concept:C0022116,
umls-concept:C0023216,
umls-concept:C0026336,
umls-concept:C0034493,
umls-concept:C0205191,
umls-concept:C0205245,
umls-concept:C0205263,
umls-concept:C0302350,
umls-concept:C1101838,
umls-concept:C1820269,
umls-concept:C1948058
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pubmed:issue |
2
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pubmed:dateCreated |
2010-7-30
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pubmed:abstractText |
We recently demonstrated in a murine model that nanoparticle-mediated delivery of pitavastatin into vascular endothelial cells effectively increased therapeutic neovascularization. For the development of a clinically applicable approach, further investigations are necessary to assess whether this novel system can induce the development of collateral arteries (arteriogenesis) in a chronic ischemia setting in larger animals.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inducing Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Carriers,
http://linkedlifedata.com/resource/pubmed/chemical/Flt1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Phthalazines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Quinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/pitavastatin,
http://linkedlifedata.com/resource/pubmed/chemical/vatalanib
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1097-6809
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
412-20
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20573471-Angiogenesis Inducing Agents,
pubmed-meshheading:20573471-Angiogenesis Inhibitors,
pubmed-meshheading:20573471-Animals,
pubmed-meshheading:20573471-Cells, Cultured,
pubmed-meshheading:20573471-Chronic Disease,
pubmed-meshheading:20573471-Collateral Circulation,
pubmed-meshheading:20573471-Disease Models, Animal,
pubmed-meshheading:20573471-Dose-Response Relationship, Drug,
pubmed-meshheading:20573471-Drug Carriers,
pubmed-meshheading:20573471-Electric Stimulation,
pubmed-meshheading:20573471-Endothelial Cells,
pubmed-meshheading:20573471-Feasibility Studies,
pubmed-meshheading:20573471-Hindlimb Suspension,
pubmed-meshheading:20573471-Humans,
pubmed-meshheading:20573471-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:20573471-Injections, Intramuscular,
pubmed-meshheading:20573471-Ischemia,
pubmed-meshheading:20573471-Male,
pubmed-meshheading:20573471-Mice,
pubmed-meshheading:20573471-Mice, Knockout,
pubmed-meshheading:20573471-Mice, Transgenic,
pubmed-meshheading:20573471-Muscle, Skeletal,
pubmed-meshheading:20573471-Nanoparticles,
pubmed-meshheading:20573471-Neovascularization, Physiologic,
pubmed-meshheading:20573471-Oxygen,
pubmed-meshheading:20573471-Phthalazines,
pubmed-meshheading:20573471-Protein Kinase Inhibitors,
pubmed-meshheading:20573471-Pyridines,
pubmed-meshheading:20573471-Quinolines,
pubmed-meshheading:20573471-Rabbits,
pubmed-meshheading:20573471-Regional Blood Flow,
pubmed-meshheading:20573471-Time Factors,
pubmed-meshheading:20573471-Vascular Endothelial Growth Factor Receptor-1
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pubmed:year |
2010
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pubmed:articleTitle |
Nanoparticle-mediated endothelial cell-selective delivery of pitavastatin induces functional collateral arteries (therapeutic arteriogenesis) in a rabbit model of chronic hind limb ischemia.
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pubmed:affiliation |
Department of Cardiovascular Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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