rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
2010-6-24
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pubmed:abstractText |
Omeprazole-induced acute interstitial nephritis (OIAIN) is a rare adverse event. It is unknown if this is an idiosyncratic immune mediated reaction or if it relates to direct drug toxicity. Individuals who are homozygous for the variant alleles of CYP2C19 are poor metabolizers of omeprazole and have a greater exposure to the drug. The aim of this study was to determine the prevalence of the CYP2C19 poor metabolizer genotype and phenotype in patients with OIAIN.
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pubmed:commentsCorrections |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1365-2125
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
69
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
516-9
|
pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:20573087-Adult,
pubmed-meshheading:20573087-Aged,
pubmed-meshheading:20573087-Aged, 80 and over,
pubmed-meshheading:20573087-Anti-Ulcer Agents,
pubmed-meshheading:20573087-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:20573087-Female,
pubmed-meshheading:20573087-Genotype,
pubmed-meshheading:20573087-Humans,
pubmed-meshheading:20573087-Male,
pubmed-meshheading:20573087-Middle Aged,
pubmed-meshheading:20573087-Nephritis, Interstitial,
pubmed-meshheading:20573087-Omeprazole,
pubmed-meshheading:20573087-Phenotype,
pubmed-meshheading:20573087-Proton Pump Inhibitors
|
pubmed:year |
2010
|
pubmed:articleTitle |
Omeprazole-induced acute interstitial nephritis is not related to CYP2C19 genotype or CYP2C19 phenotype.
|
pubmed:affiliation |
Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|