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pubmed-article:20403194pubmed:abstractTextRemission of multiple sclerosis during periods of high ovarian hormone secretion (such as pregnancy) has led to a great deal of interest in the potential for estrogens to treat autoimmune disease. Previous work has established that 17beta-estradiol can inhibit onset of experimental autoimmune encephalomyelitis (EAE), while ethinyl estradiol (EE) can reduce the severity of established disease. In the current study, the influence of estrogen receptor-alpha (ERalpha) and the G-protein coupled estrogen receptor (GPR30 or GPER) on EE's ability to treat EAE was explored.lld:pubmed
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pubmed-article:20403194pubmed:articleTitleGPR30, but not estrogen receptor-alpha, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol.lld:pubmed
pubmed-article:20403194pubmed:affiliationNeuroimmunology Research, Portland VA Medical Center, Portland, OR, USA.lld:pubmed
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