Linked Life Data

20307692

Source:http://linkedlifedata.com/resource/pubmed/id/20307692

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pubmed-article:20307692pubmed:abstractTextPolyglutamine tract-binding protein-1 (PQBP-1) is a nuclear protein that interacts with various proteins, including RNA polymerase II and the spliceosomal protein U5-15kD. PQBP-1 is known to be associated with X-linked mental retardation in which a frameshift mutation in the PQBP-1 gene occurs. In the present study, we demonstrate that PQBP-1 binds to U5-15kD via a continuous 23-residue segment within its C-terminal domain. Intriguingly, this segment is lost in the frameshift mutants of PQBP-1 associated with X-linked mental retardation. These findings suggest that the frameshift mutations in the PQBP-1 gene lead to expression of mutants lacking the ability to interact with U5-15kD.lld:pubmed
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pubmed-article:20307692pubmed:authorpubmed-author:AizawaTomoyas...lld:pubmed
pubmed-article:20307692pubmed:authorpubmed-author:KawanoKeiichi...lld:pubmed
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pubmed-article:20307692pubmed:authorpubmed-author:TakahashiMasa...lld:pubmed
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pubmed-article:20307692pubmed:authorpubmed-author:MizuguchiMine...lld:pubmed
pubmed-article:20307692pubmed:authorpubmed-author:ShinodaHiroyu...lld:pubmed
pubmed-article:20307692pubmed:copyrightInfoCopyright (c) 2010 Elsevier B.V. All rights reserved.lld:pubmed
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pubmed-article:20307692pubmed:articleTitlePolyglutamine tract-binding protein-1 binds to U5-15kD via a continuous 23-residue segment of the C-terminal domain.lld:pubmed
pubmed-article:20307692pubmed:affiliationFaculty of Pharmaceutical Sciences, University of Toyama, 2630, Sugitani, Toyama 930-0194, Japan.lld:pubmed
pubmed-article:20307692pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20307692pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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