Linked Life Data

20203683

Source:http://linkedlifedata.com/resource/pubmed/id/20203683

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pubmed-article:20203683pubmed:abstractTextImpaired left ventricular systolic function is an important cause of mortality in hemodialysis patients. An increase in the ratio of pre-ejection period (PEP) to ejection time (ET) is associated with a decrease in left ventricular systolic function. Brachial PEP (bPEP) and brachial ET (bET) can be automatically determined from an ankle-brachial index (ABI)-form device. The aim of this study was to investigate whether bPEP/bET was a useful predictor for overall and cardiovascular mortality in hemodialysis patients. We enrolled 212 hemodialysis patients in one regional hospital. The bPEP and bET were measured using an ABI-form device. The mean follow-up period was 28.3+/-5.7 months. The relative mortality risk was analyzed by Cox-regression methods. Twenty-two deaths were recorded in 212 patients (10.4%). In a multivariate analysis, the bPEP/bET (hazard ratio [HR], 1.055; P=0.047) and serum creatinine level (P=0.029) were positively and negatively associated with overall mortality, respectively. In addition, increased bPEP/bET (HR, 1.080; P=0.017), increased fasting glucose (P=0.046) and decreased serum creatinine level (P=0.004) were independent predictors for cardiovascular mortality. Our findings show that bPEP/bET, a surrogate of left ventricular systolic function, is a useful predictor for overall and cardiovascular mortality in hemodialysis patients. Screening hemodialysis patients by means of bPEP/bET may help to identify a high-risk group for increased mortality.lld:pubmed
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pubmed-article:20203683pubmed:authorpubmed-author:ChenHung-Chun...lld:pubmed
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pubmed-article:20203683pubmed:authorpubmed-author:LinTsung-Hsie...lld:pubmed
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pubmed-article:20203683pubmed:articleTitleA new systolic parameter defined as the ratio of brachial pre-ejection period to brachial ejection time predicts overall and cardiovascular mortality in hemodialysis patients.lld:pubmed
pubmed-article:20203683pubmed:affiliationDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.lld:pubmed
pubmed-article:20203683pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20203683pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed