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pubmed-article:20136841pubmed:abstractTextAlthough GPR55 is potently activated by the endogenous lysophospholipid, L-alpha-lysophosphatidylinositol (LPI), it is also thought to be sensitive to a number of cannabinoid ligands, including the prototypic CB1 receptor antagonists AM251 and SR141716A (Rimonabant). In this study we have used a range of functional assays to compare the pharmacological activity of selected cannabinoid ligands, AM251, AM281 and SR141716A with LPI in a HEK293 cell line engineered to stably express recombinant, human GPR55.lld:pubmed
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pubmed-article:20136841pubmed:articleTitleGPR55 ligands promote receptor coupling to multiple signalling pathways.lld:pubmed
pubmed-article:20136841pubmed:affiliationDivision of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.lld:pubmed
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