Source:http://linkedlifedata.com/resource/pubmed/id/19965693
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2010-1-22
|
| pubmed:abstractText |
The PROLONG randomized trial showed that a normal D-dimer (D-d) 1 month after anticoagulation suspension for unprovoked venous thromboembolism (VTE) was associated with a low risk of late recurrences (4.4% patient years). However, it is unknown whether D-d changes subsequently. The aim of this prospective multicenter study was to assess D-d time course and its relation with late recurrences in patients with normal D-d 1 month after anticoagulation suspension for a first episode of unprovoked VTE. D-d was measured with a qualitative method (Clearview Simplify D-dimer; Inverness Medical Professional Diagnostics). Patients with a normal D-d 1 month after stopping anticoagulation repeated D-d testing every 2 months for 1 year. D-d was normal in 68% (243/355) of patients 1 month after anticoagulation suspension. Patients in whom D-d became abnormal at the third month and remained abnormal afterward had a higher risk of recurrence (7/31; 27% patient years; 95% confidence interval [CI]: 12-48) than patients in whom D-d remained normal at the third month and afterward (4/149; 2.9% patient years; 95% CI: 1-7; adjusted hazard ratio: 7.9; 95% CI: 2.1-30; P = .002). Repeated D-d testing after anticoagulation suspension for a first episode of unprovoked VTE could help tailor the duration of treatment. This trial is registered at http://clinicaltrials.gov as NCT00266045.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1528-0020
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| pubmed:author |
pubmed-author:CosmiBenildeB,
pubmed-author:GhirarduzziAngeloA,
pubmed-author:LegnaniCristinaC,
pubmed-author:MarongiuFrancescoF,
pubmed-author:PROLONG Investigators (on behalf of Italian Federation of...,
pubmed-author:PalaretiGualtieroG,
pubmed-author:PengoVittorioV,
pubmed-author:PoliDanielaD,
pubmed-author:PriscoDomenicoD,
pubmed-author:TestaSophieS,
pubmed-author:TosettoAlbertoA,
pubmed-author:TripodiArmandoA
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
21
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| pubmed:volume |
115
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
481-8
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| pubmed:meshHeading |
pubmed-meshheading:19965693-Adolescent,
pubmed-meshheading:19965693-Adult,
pubmed-meshheading:19965693-Aged,
pubmed-meshheading:19965693-Aged, 80 and over,
pubmed-meshheading:19965693-Anticoagulants,
pubmed-meshheading:19965693-Blood Chemical Analysis,
pubmed-meshheading:19965693-Blood Coagulation Disorders,
pubmed-meshheading:19965693-Female,
pubmed-meshheading:19965693-Fibrin Fibrinogen Degradation Products,
pubmed-meshheading:19965693-Follow-Up Studies,
pubmed-meshheading:19965693-Humans,
pubmed-meshheading:19965693-Male,
pubmed-meshheading:19965693-Middle Aged,
pubmed-meshheading:19965693-Periodicity,
pubmed-meshheading:19965693-Predictive Value of Tests,
pubmed-meshheading:19965693-Prognosis,
pubmed-meshheading:19965693-Prospective Studies,
pubmed-meshheading:19965693-Recurrence,
pubmed-meshheading:19965693-Venous Thromboembolism,
pubmed-meshheading:19965693-Withholding Treatment
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| pubmed:year |
2010
|
| pubmed:articleTitle |
Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: the PROLONG II prospective study.
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| pubmed:affiliation |
Department of Angiology and Blood Coagulation, Marino Golinelli University Hospital St Orsola-Malpighi, Bologna, Italy. benilde.cosmi@unibo.it
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| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|