| pubmed-article:19837676 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19837676 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:19837676 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:19837676 | lifeskim:mentions | umls-concept:C0387583 | lld:lifeskim |
| pubmed-article:19837676 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:19837676 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19837676 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19837676 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:19837676 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:19837676 | pubmed:issue | 51 | lld:pubmed |
| pubmed-article:19837676 | pubmed:dateCreated | 2009-12-16 | lld:pubmed |
| pubmed-article:19837676 | pubmed:abstractText | Abnormal transforming growth factor-beta (TGF-beta) signaling is a critical contributor to the pathogenesis of various human diseases ranging from tissue fibrosis to tumor formation. Excessive TGF-beta signaling stimulates fibrotic responses. Recent research has focused in the main on the antiproliferative effects of TGF-beta in fibroblasts, and it is presently understood that TGF-beta-stimulated cyclooxygenase-2 (COX-2) induction in fibroblasts is essential for antifibroproliferative effects of TGF-beta. Both TGF-beta and COX-2 have been implicated in tumor growth, invasion, and metastasis, and therefore tumor-associated fibroblasts are a recent topic of interest. Here we report the identification of positive and negative regulatory factors of COX-2 expression induced by TGF-beta as determined using proteomic approaches. We show that TGF-beta coordinately up-regulates three factors, heterogeneous nuclear ribonucleoprotein A/B (HNRPAB), nucleotide diphosphate kinase A (NDPK A), and nucleotide diphosphate kinase A (NDPK B). Functional pathway analysis showed that HNRPAB augments mRNA and protein levels of COX-2 and subsequent prostaglandin E(2) (PGE(2)) production by suppressing degradation of COX-2 mRNA. In contrast, NDPK A and NDPK B attenuated mRNA and protein levels of COX-2 by affecting TGF-beta-Smad2/3/4 signaling at the receptor level. Collectively, we report on a new regulatory pathway of TGF-beta in controlling expression of COX-2 in fibroblasts, which advances our understanding of pathophysiological mechanisms of TGF-beta. | lld:pubmed |
| pubmed-article:19837676 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19837676 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19837676 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19837676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19837676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19837676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19837676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19837676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19837676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19837676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19837676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19837676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19837676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19837676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19837676 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19837676 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19837676 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:19837676 | pubmed:author | pubmed-author:NagaiRyozoR | lld:pubmed |
| pubmed-article:19837676 | pubmed:author | pubmed-author:SuzukiToruT | lld:pubmed |
| pubmed-article:19837676 | pubmed:author | pubmed-author:IshidaJunichi... | lld:pubmed |
| pubmed-article:19837676 | pubmed:author | pubmed-author:SawakiDaigoD | lld:pubmed |
| pubmed-article:19837676 | pubmed:author | pubmed-author:MatsumuraTaka... | lld:pubmed |
| pubmed-article:19837676 | pubmed:author | pubmed-author:AizawaKenichi... | lld:pubmed |
| pubmed-article:19837676 | pubmed:author | pubmed-author:MunemasaYoshi... | lld:pubmed |
| pubmed-article:19837676 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19837676 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:19837676 | pubmed:volume | 284 | lld:pubmed |
| pubmed-article:19837676 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19837676 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19837676 | pubmed:pagination | 35861-71 | lld:pubmed |
| pubmed-article:19837676 | pubmed:dateRevised | 2010-12-21 | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:meshHeading | pubmed-meshheading:19837676... | lld:pubmed |
| pubmed-article:19837676 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19837676 | pubmed:articleTitle | Regulation of transforming growth factor-beta-dependent cyclooxygenase-2 expression in fibroblasts. | lld:pubmed |
| pubmed-article:19837676 | pubmed:affiliation | Departments of Cardiovascular Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. | lld:pubmed |
| pubmed-article:19837676 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19837676 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:17126 | entrezgene:pubmed | pubmed-article:19837676 | lld:entrezgene |
| entrez-gene:17127 | entrezgene:pubmed | pubmed-article:19837676 | lld:entrezgene |
| entrez-gene:17128 | entrezgene:pubmed | pubmed-article:19837676 | lld:entrezgene |
| entrez-gene:18102 | entrezgene:pubmed | pubmed-article:19837676 | lld:entrezgene |
| entrez-gene:18103 | entrezgene:pubmed | pubmed-article:19837676 | lld:entrezgene |
| entrez-gene:19225 | entrezgene:pubmed | pubmed-article:19837676 | lld:entrezgene |
| entrez-gene:21803 | entrezgene:pubmed | pubmed-article:19837676 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19837676 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19837676 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19837676 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19837676 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19837676 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19837676 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19837676 | lld:entrezgene |
