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rdf:type |
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lifeskim:mentions |
umls-concept:C0003483,
umls-concept:C0068355,
umls-concept:C0086418,
umls-concept:C0086982,
umls-concept:C0205548,
umls-concept:C0805732,
umls-concept:C0851285,
umls-concept:C1135918,
umls-concept:C1335960,
umls-concept:C1366753,
umls-concept:C1456389,
umls-concept:C1548425
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pubmed:issue |
1
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pubmed:dateCreated |
2009-12-18
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pubmed:abstractText |
Oxidative stress mediated by Nox1- and Nox4-based NADPH oxidase (Nox) plays a key role in vascular diseases. The molecular mechanisms involved in the regulation of Nox are not entirely elucidated. Because JAK/STAT regulates many genes linked to inflammation, cell proliferation, and differentiation, we questioned whether this pathway is involved in the regulation of Nox1 and Nox4 in human aortic smooth muscle cells (SMCs).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CYBA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/JAK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/NOX1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/NOX4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/neutrophil cytosol factor 67K,
http://linkedlifedata.com/resource/pubmed/chemical/neutrophil cytosolic factor 1
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-12
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pubmed:meshHeading |
pubmed-meshheading:19834108-Aorta, Thoracic,
pubmed-meshheading:19834108-Cells, Cultured,
pubmed-meshheading:19834108-Enzyme Activation,
pubmed-meshheading:19834108-Enzyme Inhibitors,
pubmed-meshheading:19834108-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:19834108-Humans,
pubmed-meshheading:19834108-Interferon-gamma,
pubmed-meshheading:19834108-Janus Kinase 2,
pubmed-meshheading:19834108-Muscle, Smooth, Vascular,
pubmed-meshheading:19834108-NADPH Oxidase,
pubmed-meshheading:19834108-Phosphoproteins,
pubmed-meshheading:19834108-Promoter Regions, Genetic,
pubmed-meshheading:19834108-STAT1 Transcription Factor,
pubmed-meshheading:19834108-STAT3 Transcription Factor,
pubmed-meshheading:19834108-Signal Transduction,
pubmed-meshheading:19834108-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells.
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pubmed:affiliation |
Institute of Cellular Biology and Pathology "Nicolae Simionescu," 8, BP Hasdeu St, Bucharest, PO Box 35-14, Romania.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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