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rdf:type |
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lifeskim:mentions |
umls-concept:C0109317,
umls-concept:C0164786,
umls-concept:C0334227,
umls-concept:C0346647,
umls-concept:C0524914,
umls-concept:C0752312,
umls-concept:C0812228,
umls-concept:C0851827,
umls-concept:C1150579,
umls-concept:C1332823,
umls-concept:C1333340,
umls-concept:C1366882,
umls-concept:C1370600,
umls-concept:C1514485,
umls-concept:C1701901,
umls-concept:C1704259,
umls-concept:C1705767,
umls-concept:C1705791,
umls-concept:C1705987,
umls-concept:C2349975
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pubmed:issue |
1
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pubmed:dateCreated |
2009-12-18
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pubmed:abstractText |
We previously detected CXCR4 expression in pancreatic intraepithelial neoplasia (PanIN) tissues and demonstrated CXCR4-enhanced proliferation of PanIN cells. Our objective was to determine if the CXCR4 targets AKT and ERK mediate CXCR4-dependent PanIN and pancreatic cancer proliferation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz...,
http://linkedlifedata.com/resource/pubmed/chemical/Butadienes,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL12,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4,
http://linkedlifedata.com/resource/pubmed/chemical/U 0126
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1536-4828
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19820417-Animals,
pubmed-meshheading:19820417-Butadienes,
pubmed-meshheading:19820417-Cell Line, Tumor,
pubmed-meshheading:19820417-Cell Proliferation,
pubmed-meshheading:19820417-Chemokine CXCL12,
pubmed-meshheading:19820417-Chromones,
pubmed-meshheading:19820417-Enzyme Inhibitors,
pubmed-meshheading:19820417-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:19820417-Humans,
pubmed-meshheading:19820417-Immunohistochemistry,
pubmed-meshheading:19820417-Mice,
pubmed-meshheading:19820417-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:19820417-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:19820417-Morpholines,
pubmed-meshheading:19820417-Nitriles,
pubmed-meshheading:19820417-Pancreatic Neoplasms,
pubmed-meshheading:19820417-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:19820417-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:19820417-Receptors, CXCR4,
pubmed-meshheading:19820417-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
Chemokine receptor CXCR4 enhances proliferation in pancreatic cancer cells through AKT and ERK dependent pathways.
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pubmed:affiliation |
City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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