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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-9-21
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pubmed:abstractText |
Acute lung injury (ALI) is a prevalent disease associated with high mortality. 12/15-lipoxygenase (12/15-LO) is an enzyme producing 12-hydroxyeicosatetraenoic acid (HETE) and 15-HETE from arachidonic acid. To test whether 12/15-LO is involved in increasing vascular permeability in the lung, we investigated the role of 12/15-LO in murine models of LPS-induced pulmonary inflammation and clinically relevant acid-induced ALI. The vascular permeability increase upon LPS inhalation was abolished in Alox15(-/-) mice lacking 12/15-LO and in wild-type mice after pharmacological blockade of 12/15-LO. Alox15(-/-) mice also showed improved gas exchange, reduced permeability increase, and prolonged survival in the acid-induced ALI model. Bone marrow chimeras and reconstitution experiments revealed that 12-HETE produced by hematopoietic cells regulates vascular permeability through a CXCR2-dependent mechanism. Our findings suggest that 12/15-LO-derived 12-HETE is a key mediator of vascular permeability in acute lung injury.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/12-Hydroxy-5,8,10,14-eicosatetraenoi...,
http://linkedlifedata.com/resource/pubmed/chemical/Alox15 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonate 12-Lipoxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonate 15-Lipoxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/Caffeic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/cinnamyl-3,4-dihydroxycyanocinnamate
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1550-6606
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
183
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4715-22
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pubmed:dateRevised |
2011-7-15
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pubmed:meshHeading |
pubmed-meshheading:19752233-12-Hydroxy-5,8,10,14-eicosatetraenoic Acid,
pubmed-meshheading:19752233-Acute Lung Injury,
pubmed-meshheading:19752233-Animals,
pubmed-meshheading:19752233-Arachidonate 12-Lipoxygenase,
pubmed-meshheading:19752233-Arachidonate 15-Lipoxygenase,
pubmed-meshheading:19752233-Caffeic Acids,
pubmed-meshheading:19752233-Capillary Permeability,
pubmed-meshheading:19752233-Cells, Cultured,
pubmed-meshheading:19752233-Disease Models, Animal,
pubmed-meshheading:19752233-Humans,
pubmed-meshheading:19752233-Inflammation Mediators,
pubmed-meshheading:19752233-Lipopolysaccharides,
pubmed-meshheading:19752233-Lipoxygenase Inhibitors,
pubmed-meshheading:19752233-Mice,
pubmed-meshheading:19752233-Mice, Inbred BALB C,
pubmed-meshheading:19752233-Mice, Inbred C57BL,
pubmed-meshheading:19752233-Mice, Knockout,
pubmed-meshheading:19752233-Microcirculation,
pubmed-meshheading:19752233-Multienzyme Complexes,
pubmed-meshheading:19752233-Survival Analysis
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pubmed:year |
2009
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pubmed:articleTitle |
Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).
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pubmed:affiliation |
Robert M. Berne Cardiovascular Research Center, Department of Anesthesiology and Critical Care Medicine, University of Muenster, Albert-Schweitzer Strasse 33, Muenster 48149, Germany. zarbock@uni-muenster.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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