Source:http://linkedlifedata.com/resource/pubmed/id/19657647
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2010-1-11
|
| pubmed:abstractText |
The purpose of this study was to prospectively determine the accuracy of low-dose computed tomography coronary angiography (CTCA) for the diagnosis of functionally relevant coronary artery disease (CAD) using cardiac magnetic resonance (CMR) as a standard of reference. Forty-one consecutive patients (age 64 +/- 10 years) underwent k-space and time broad-use linear acquisition speed-up technique accelerated CMR (1.5 T) and dual-source CTCA using prospective electrocardiography gating within 1 day. CTCA lesions were analysed and diameter stenoses of more than 50% and more than 75% were compared with CMR findings taken as the reference standard for assessing the functional relevance of CAD. CMR revealed perfusion defects in 21/41 patients (51%). A total of 569 coronary segments were analysed with low-dose CTCA. The image quality of low-dose CTCA was diagnostic in 566/569 segments (99.5%) in 39/41 patients (95%). Low-dose CTCA revealed stenoses of more than 50% in 58/123 coronary arteries (47.2%) in 24/41 patients (59%) and more than 75% stenoses in 46/123 coronary arteries (37.4%) in 23/41 patients (56%). Using a greater than 50% diameter stenosis, low-dose CTCA yielded the following per artery sensitivity, specificity, positive and negative predictive values, and accuracy for the detection of perfusion defects: 89%, 79%, 72%, 92% and 83%, respectively. Low-dose CTCA is reliable for ruling out functionally relevant CAD, but is a poor predictor of myocardial ischaemia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1432-1084
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| pubmed:author |
pubmed-author:AlkadhiHatemH,
pubmed-author:AzemajNaimN,
pubmed-author:BaumuellerStephanS,
pubmed-author:BoesigerPeterP,
pubmed-author:DonatiOlivio FOF,
pubmed-author:GrünenfelderJürgJ,
pubmed-author:KozerkeSebastianS,
pubmed-author:LeschkaSebastianS,
pubmed-author:MarincekBorutB,
pubmed-author:PlassAndréA,
pubmed-author:ScheffelHansH,
pubmed-author:StolzmannPaulP
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
56-64
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| pubmed:meshHeading |
pubmed-meshheading:19657647-Adult,
pubmed-meshheading:19657647-Aged,
pubmed-meshheading:19657647-Body Burden,
pubmed-meshheading:19657647-Coronary Angiography,
pubmed-meshheading:19657647-Coronary Artery Disease,
pubmed-meshheading:19657647-Female,
pubmed-meshheading:19657647-Humans,
pubmed-meshheading:19657647-Male,
pubmed-meshheading:19657647-Middle Aged,
pubmed-meshheading:19657647-Myocardial Ischemia,
pubmed-meshheading:19657647-Perfusion Imaging,
pubmed-meshheading:19657647-Radiation Dosage,
pubmed-meshheading:19657647-Radiation Protection,
pubmed-meshheading:19657647-Reproducibility of Results,
pubmed-meshheading:19657647-Sensitivity and Specificity,
pubmed-meshheading:19657647-Tomography, X-Ray Computed
|
| pubmed:year |
2010
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| pubmed:articleTitle |
Low-dose CT coronary angiography for the prediction of myocardial ischaemia.
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| pubmed:affiliation |
Institute of Diagnostic Radiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|