Linked Life Data

1951236

Source:http://linkedlifedata.com/resource/pubmed/id/1951236

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1991-12-17
pubmed:abstractText
In order to develop an experimental rodent model, we administered 2 ml (10(8) organisms/ml) broth culture of any of four human isolated strains of Helicobacter pylori by the oral route on a one-time basis to both BALB/c nude and BALB/c euthymic mice. After 20-wk examination, we have successfully demonstrated that the gastric mucosa of nude mice was continuously, and that of euthymic mice, temporarily (for 2 wk), colonized by orally administered, freshly isolated strains obtained from humans with gastritis, gastric ulcer, and duodenal ulcer, but never by the established strain. After colonization, gastritis and duodenitis were produced, and the presence of bacteria in gastric mucus was pathologically proved in all infected animals. We have confirmed that such colonization is always established when a large dose of a freshly isolated strain of H. pylori is administered at one time. We believe that this is the first reported rodent model of H. pylori-associated gastritis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9270
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1596-603
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
New small animal model for human gastric Helicobacter pylori infection: success in both nude and euthymic mice.
pubmed:affiliation
First Department of Internal Medicine, Yamaguchi University School of Medicine.
pubmed:publicationType
Journal Article