| pubmed-article:19508729 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19508729 | lifeskim:mentions | umls-concept:C0030297 | lld:lifeskim |
| pubmed-article:19508729 | lifeskim:mentions | umls-concept:C0538674 | lld:lifeskim |
| pubmed-article:19508729 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:19508729 | lifeskim:mentions | umls-concept:C0598934 | lld:lifeskim |
| pubmed-article:19508729 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:19508729 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:19508729 | pubmed:dateCreated | 2009-6-29 | lld:pubmed |
| pubmed-article:19508729 | pubmed:abstractText | Pancreatic cancer (PaCa) is a fatal human cancer due to its exceptional resistance to all current anticancer therapies. The cytoprotective enzyme heme oxygenase-1 (HO-1) is significantly overexpressed in PaCa and seems to play an important role in cancer resistance to anticancer treatment. The inhibition of HO-1 sensitized PaCa cells to chemo- and radiotherapy in vitro. Therefore, we investigated the effects of HO-1 and its metabolites biliverdin, carbon monoxide and iron on PaCa cells. PaCa cell lines with divergent HO-1 expression patterns were used in a murine orthotopic cancer model. HO-1 expression and activity was regulated by zinc (inhibition) and cobalt (induction) protoporphyrin. Furthermore, the influence of cellular HO-1 levels and its metabolites on effects of standard chemotherapy with gemcitabine was tested in vivo and in vitro. | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19508729 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19508729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19508729 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19508729 | pubmed:issn | 1476-4598 | lld:pubmed |
| pubmed-article:19508729 | pubmed:author | pubmed-author:FriessHelmutH | lld:pubmed |
| pubmed-article:19508729 | pubmed:author | pubmed-author:KünzliBeat... | lld:pubmed |
| pubmed-article:19508729 | pubmed:author | pubmed-author:BerberatPasca... | lld:pubmed |
| pubmed-article:19508729 | pubmed:author | pubmed-author:HennigRenéR | lld:pubmed |
| pubmed-article:19508729 | pubmed:author | pubmed-author:NobilingRaine... | lld:pubmed |
| pubmed-article:19508729 | pubmed:author | pubmed-author:MeuerStefan... | lld:pubmed |
| pubmed-article:19508729 | pubmed:author | pubmed-author:RamanauskasTa... | lld:pubmed |
| pubmed-article:19508729 | pubmed:author | pubmed-author:MitkusTomasT | lld:pubmed |
| pubmed-article:19508729 | pubmed:author | pubmed-author:NuhnPhilippP | lld:pubmed |
| pubmed-article:19508729 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19508729 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:19508729 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19508729 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19508729 | pubmed:pagination | 37 | lld:pubmed |
| pubmed-article:19508729 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:19508729 | pubmed:meshHeading | pubmed-meshheading:19508729... | lld:pubmed |
| pubmed-article:19508729 | pubmed:meshHeading | pubmed-meshheading:19508729... | lld:pubmed |
| pubmed-article:19508729 | pubmed:meshHeading | pubmed-meshheading:19508729... | lld:pubmed |
| pubmed-article:19508729 | pubmed:meshHeading | pubmed-meshheading:19508729... | lld:pubmed |
| pubmed-article:19508729 | pubmed:meshHeading | pubmed-meshheading:19508729... | lld:pubmed |
| pubmed-article:19508729 | pubmed:meshHeading | pubmed-meshheading:19508729... | lld:pubmed |
| pubmed-article:19508729 | pubmed:meshHeading | pubmed-meshheading:19508729... | lld:pubmed |
| pubmed-article:19508729 | pubmed:meshHeading | pubmed-meshheading:19508729... | lld:pubmed |
| pubmed-article:19508729 | pubmed:meshHeading | pubmed-meshheading:19508729... | lld:pubmed |
| pubmed-article:19508729 | pubmed:meshHeading | pubmed-meshheading:19508729... | lld:pubmed |
| pubmed-article:19508729 | pubmed:meshHeading | pubmed-meshheading:19508729... | lld:pubmed |
| pubmed-article:19508729 | pubmed:meshHeading | pubmed-meshheading:19508729... | lld:pubmed |
| pubmed-article:19508729 | pubmed:meshHeading | pubmed-meshheading:19508729... | lld:pubmed |
| pubmed-article:19508729 | pubmed:meshHeading | pubmed-meshheading:19508729... | lld:pubmed |
