Linked Life Data

19497624

Source:http://linkedlifedata.com/resource/pubmed/id/19497624

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-7-14
pubmed:abstractText
To investigate the effect of oral and transdermal estrogen replacement therapy (ERT) on the expression of different estrogen receptor (ER) subtypes and the secretion of immunoregulatory cytokines, we performed a clinical investigation on previously healthy women who had undergone a total hysterectomy and bilateral salpingo-oopherectomy. These women were randomly distributed into two groups: an oral ERT group and transdermal ERT group. Before and after ERT, the serum levels of estradiol (E2) and follicle stimulating hormone (FSH) were measured, ERalpha and ERbeta expression of peripheral blood T lymphocytes was tested, and secretion of specific immunoregulatory cytokines (IFNgamma, IL-2 and IL-4) by T lymphocytes was examined. Our results confirm that for both groups, the serum E2 level was increased after ERT (P<0.01) and the serum FSH level was decreased after ERT (P<0.01), with no significant difference in hormone levels between the two groups. ERalpha expression by T lymphocytes was significantly higher after ERT than before (P<0.01) in both groups. Levels of type 1 cytokines (IL-2 and IFNgamma), which were secreted by T helper 1 (Th1), after ERT were substantially decreased. The level of type 2 cytokine (IL-4), which were secreted by T helper 2 (Th2), was significantly increased after ERT (P<0.01 for the oral group and P<0.05 for the transdermal group). In summary, both oral and transdermal ERT increased serum E2 levels, decreased serum FSH levels and relieved the effects of peri-menopausal symptoms. These data suggest that both oral and transdermal ERT act to improve the balance of Th1/Th2 cytokines by the effects of estrogen potentially acting in T lymphocytes mainly through ERalpha.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1872-7603
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-96
pubmed:dateRevised
2010-2-22
pubmed:meshHeading
pubmed-meshheading:19497624-Administration, Cutaneous, pubmed-meshheading:19497624-Administration, Oral, pubmed-meshheading:19497624-Cells, Cultured, pubmed-meshheading:19497624-Cytokines, pubmed-meshheading:19497624-Endometriosis, pubmed-meshheading:19497624-Estradiol, pubmed-meshheading:19497624-Estrogen Receptor alpha, pubmed-meshheading:19497624-Estrogen Receptor beta, pubmed-meshheading:19497624-Estrogen Replacement Therapy, pubmed-meshheading:19497624-Estrogens, pubmed-meshheading:19497624-Female, pubmed-meshheading:19497624-Follicle Stimulating Hormone, pubmed-meshheading:19497624-Gene Expression Regulation, pubmed-meshheading:19497624-Humans, pubmed-meshheading:19497624-Hysterectomy, pubmed-meshheading:19497624-Leiomyoma, pubmed-meshheading:19497624-Menopause, Premature, pubmed-meshheading:19497624-Middle Aged, pubmed-meshheading:19497624-Ovariectomy, pubmed-meshheading:19497624-T-Lymphocytes, pubmed-meshheading:19497624-Uterine Neoplasms
pubmed:year
2009
pubmed:articleTitle
Effects of estrogen replacement therapy on estrogen receptor expression and immunoregulatory cytokine secretion in surgically induced menopausal women.
pubmed:affiliation
Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, 419 Fang Xie Road, Shanghai 200011, China.
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't