Source:http://linkedlifedata.com/resource/pubmed/id/19481939
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2009-7-13
|
| pubmed:abstractText |
In contrast with Steinert's disease (DM1), type 2 muscular dystrophy (DM2) is not known to be associated with a high prevalence of cardiac involvement. Our objective was to compare the results of detailed cardiac investigations in populations of DM2 and DM1 patients, and in controls. Thirty-eight DM2 patients (17 males; age=57.1+/-15.2years) were investigated for possible heart involvement, and their results compared with 76 age-sex matched DM1 patients and 76 controls. Cardiac abnormalities were present in 15 DM2 patients, including conductive defects in 14, systolic dysfunction in 6, supraventricular arrhythmias in 6 and stroke in 5 patients and were significantly more frequent than in controls. When compared to DM1 patients, conductive defects were less frequent, supraventricular arrhythmias had similar prevalence and there was a trend towards more frequent left ventricular dysfunction in DM2 patients. Our study suggests that systematic cardiac investigations should be recommended in these patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1873-2364
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
468-72
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:19481939-Adult,
pubmed-meshheading:19481939-Aged,
pubmed-meshheading:19481939-Arrhythmias, Cardiac,
pubmed-meshheading:19481939-Case-Control Studies,
pubmed-meshheading:19481939-Comorbidity,
pubmed-meshheading:19481939-Echocardiography,
pubmed-meshheading:19481939-Electrocardiography,
pubmed-meshheading:19481939-Female,
pubmed-meshheading:19481939-Genetic Predisposition to Disease,
pubmed-meshheading:19481939-Genetic Testing,
pubmed-meshheading:19481939-Heart Arrest,
pubmed-meshheading:19481939-Heart Ventricles,
pubmed-meshheading:19481939-Humans,
pubmed-meshheading:19481939-Male,
pubmed-meshheading:19481939-Mass Screening,
pubmed-meshheading:19481939-Middle Aged,
pubmed-meshheading:19481939-Myocardium,
pubmed-meshheading:19481939-Myotonic Disorders,
pubmed-meshheading:19481939-Prevalence,
pubmed-meshheading:19481939-Stroke,
pubmed-meshheading:19481939-Ventricular Dysfunction, Left
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Left ventricular dysfunction and cardiac arrhythmias are frequent in type 2 myotonic dystrophy: a case control study.
|
| pubmed:affiliation |
Myology Institute, Pitié-Salpétrière Hospital, APHP, 47-83 boulevard de l'Hôpital, Paris Cedex 13, France. karim.wahbi@psl.aphp.fr
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|