rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
6
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pubmed:dateCreated |
2009-10-19
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pubmed:abstractText |
Tryptophan catabolism via the kynurenine pathway, mediated by indoleamine 2,3-dioxygenase (IDO), is a mechanism involved in tumor immunoresistance. Positron emission tomography (PET) with alpha-[(11)C]methyl-L-tryptophan (AMT) can quantify transport and metabolism of tryptophan in infiltrating gliomas and glioneuronal tumors. In the present study, we investigated whether increased tryptophan metabolism in brain tumors measured by PET is related to expression of IDO in resected brain tumor specimens.
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pubmed:grant |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:issn |
1860-2002
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pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
11
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
460-6
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:19434461-Adolescent,
pubmed-meshheading:19434461-Adult,
pubmed-meshheading:19434461-Aged,
pubmed-meshheading:19434461-Brain Neoplasms,
pubmed-meshheading:19434461-Child,
pubmed-meshheading:19434461-Child, Preschool,
pubmed-meshheading:19434461-Diagnostic Imaging,
pubmed-meshheading:19434461-Female,
pubmed-meshheading:19434461-Glioma,
pubmed-meshheading:19434461-Humans,
pubmed-meshheading:19434461-Immunohistochemistry,
pubmed-meshheading:19434461-Indoleamine-Pyrrole 2,3,-Dioxygenase,
pubmed-meshheading:19434461-Male,
pubmed-meshheading:19434461-Middle Aged,
pubmed-meshheading:19434461-Positron-Emission Tomography,
pubmed-meshheading:19434461-Tryptophan,
pubmed-meshheading:19434461-Young Adult
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pubmed:articleTitle |
Imaging correlates of differential expression of indoleamine 2,3-dioxygenase in human brain tumors.
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pubmed:affiliation |
Carman and Ann Adams Department of Pediatrics, School of Medicine, Wayne State University, Detroit, MI, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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