| pubmed-article:19426837 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19426837 | lifeskim:mentions | umls-concept:C0521009 | lld:lifeskim |
| pubmed-article:19426837 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:19426837 | lifeskim:mentions | umls-concept:C1704263 | lld:lifeskim |
| pubmed-article:19426837 | lifeskim:mentions | umls-concept:C1155000 | lld:lifeskim |
| pubmed-article:19426837 | lifeskim:mentions | umls-concept:C1333574 | lld:lifeskim |
| pubmed-article:19426837 | lifeskim:mentions | umls-concept:C0071649 | lld:lifeskim |
| pubmed-article:19426837 | lifeskim:mentions | umls-concept:C0059438 | lld:lifeskim |
| pubmed-article:19426837 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:19426837 | pubmed:dateCreated | 2009-7-6 | lld:pubmed |
| pubmed-article:19426837 | pubmed:abstractText | Although green tea polyphenol catechin is considered as a potential anti-inflammatory agent, its effect on bacterial component-induced inflammation has been poorly investigated. We examined the capacity of epigallocatechin gallate (EGCG) to regulate leukocyte responses to bacterial chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (fMLF), which is recognized by a human G protein-coupled receptor FPR on phagocytic leukocytes. Pretreatment of human monocytic cells or FPR-transfected rat basophilic leukemia cells (ETFR cells) with EGCG significantly inhibited fMLF-induced chemotaxis. Intraperitoneal administration of EGCG in mice suppressed fMLF-induced leukocyte infiltration into the air pouch created in the skin. Mechanistic studies revealed that EGCG dose-dependently suppressed fMLF-induced calcium flux in monocytic cells and ETFR cells. fMLF-induced ETFR cell migration was significantly inhibited by a specific MEK1/2 inhibitor, PD98059, which was associated with reduction in fMLF-induced ERK1/2 phosphorylation. These results suggest that EGCG inhibits FPR-mediated leukocyte activation thus is a promising anti-inflammatory compound. | lld:pubmed |
| pubmed-article:19426837 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19426837 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19426837 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19426837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19426837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19426837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19426837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19426837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19426837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19426837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19426837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19426837 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19426837 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19426837 | pubmed:issn | 1878-1705 | lld:pubmed |
| pubmed-article:19426837 | pubmed:author | pubmed-author:LeYingyingY | lld:pubmed |
| pubmed-article:19426837 | pubmed:author | pubmed-author:WangJi MingJM | lld:pubmed |
| pubmed-article:19426837 | pubmed:author | pubmed-author:CuiYouhongY | lld:pubmed |
| pubmed-article:19426837 | pubmed:author | pubmed-author:RuanLingfeiL | lld:pubmed |
| pubmed-article:19426837 | pubmed:author | pubmed-author:WangOumeiO | lld:pubmed |
| pubmed-article:19426837 | pubmed:author | pubmed-author:ZhuJingjingJ | lld:pubmed |
| pubmed-article:19426837 | pubmed:author | pubmed-author:HouXinweiX | lld:pubmed |
| pubmed-article:19426837 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19426837 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:19426837 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19426837 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19426837 | pubmed:pagination | 1126-30 | lld:pubmed |
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| pubmed-article:19426837 | pubmed:meshHeading | pubmed-meshheading:19426837... | lld:pubmed |
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| pubmed-article:19426837 | pubmed:meshHeading | pubmed-meshheading:19426837... | lld:pubmed |
| pubmed-article:19426837 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19426837 | pubmed:articleTitle | The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor FPR. | lld:pubmed |
| pubmed-article:19426837 | pubmed:affiliation | Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, China. | lld:pubmed |
| pubmed-article:19426837 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19426837 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19426837 | lld:pubmed |
