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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5-6
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pubmed:dateCreated |
2009-5-21
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pubmed:abstractText |
Stroke is a common complex trait and does not follow Mendelian pattern of inheritance. Gene-gene or gene-environment interactions may be responsible for the complex trait. How the interactions contribute to stroke is still under research. This study aimed to explore the association between gene-gene interactions and stroke in Chinese in a large case-control study. Nearly 4,000 participants were recruited from seven clinical centers. Eight variants in five candidate genes were examined for stroke risk. Gene-gene interactions were explored by using Generalized Multifactor Dimensionality Reduction (GMDR). A significant gene-gene interaction was found by GMDR. The best model including MTHFR C677T, ALOX5AP T2354A and NOTCH3 C381T scored 10 for Cross-Validation Consistency and 9 for Sign Test (P = 0.0107). The individuals with combination of MTHFR 677TT, ALOX5AP 2354AA and NOTCH3 381TT/TC had a significantly higher risk of thrombotic stroke (OR 3.165, 95% CI 1.461-6.858, P = 0.003). Our results show that combination of these alleles conferred higher risk for stroke than single risk allele. The gene-gene interaction may serve as a novel area for stroke research. The three-locus combination may change the susceptibility of particular subjects to the disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1432-1203
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pubmed:author |
pubmed-author:BaiYongyiY,
pubmed-author:ChenJingzhouJ,
pubmed-author:HuiRutaiR,
pubmed-author:LiuJunhaoJ,
pubmed-author:LiuZheZ,
pubmed-author:SongXiaodongX,
pubmed-author:SunKaiK,
pubmed-author:WangHuH,
pubmed-author:WangXiaojianX,
pubmed-author:WangYiboY,
pubmed-author:XinYingY,
pubmed-author:ZhangWeiliW
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pubmed:issnType |
Electronic
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
649-56
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19373490-5-Lipoxygenase-Activating Proteins,
pubmed-meshheading:19373490-Aged,
pubmed-meshheading:19373490-Alleles,
pubmed-meshheading:19373490-Asian Continental Ancestry Group,
pubmed-meshheading:19373490-Carrier Proteins,
pubmed-meshheading:19373490-Case-Control Studies,
pubmed-meshheading:19373490-DNA Mutational Analysis,
pubmed-meshheading:19373490-Female,
pubmed-meshheading:19373490-Gene Frequency,
pubmed-meshheading:19373490-Genetic Predisposition to Disease,
pubmed-meshheading:19373490-Genotype,
pubmed-meshheading:19373490-Humans,
pubmed-meshheading:19373490-Intracranial Thrombosis,
pubmed-meshheading:19373490-Logistic Models,
pubmed-meshheading:19373490-Male,
pubmed-meshheading:19373490-Membrane Proteins,
pubmed-meshheading:19373490-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:19373490-Middle Aged,
pubmed-meshheading:19373490-Models, Genetic,
pubmed-meshheading:19373490-Receptors, Notch,
pubmed-meshheading:19373490-Risk Factors,
pubmed-meshheading:19373490-Stroke
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pubmed:year |
2009
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pubmed:articleTitle |
Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case-control study.
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pubmed:affiliation |
Sino-German Laboratory, Molecular Medicine, Key Laboratory for Clinical Cardiovascular Genetics of Ministry of Education, FuWai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. ljh.bb.bj@gmail.com
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Multicenter Study
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