Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1991-12-11
pubmed:abstractText
Epidermal growth factor receptor can be used as a biological marker in tumours. We examined 199 samples from 150 patients with ovarian cancer first by using a single point screen, then by full Scatchard analysis, over a concentration range between 0.086-16.6 nM. Taking as positive those samples which showed a 20% difference between total binding and non specific binding, the EGFR was present in 39.7% of samples ranging from 36.4% in those tumours which were classified as being mucinous to 47.7% in the undifferentiated group. Thirty-six samples had a low affinity component (Kd greater than 1 nM), 27 had a high affinity component (Kd less than 1 nM) and 16 had both high and low affinity components to the EGFR. There was no statistical difference between degree of differentiation of the tumour and the presence of the EGFR nor between stage of the disease and EGFR presence.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1931614-2311071, http://linkedlifedata.com/resource/pubmed/commentcorrection/1931614-2775686, http://linkedlifedata.com/resource/pubmed/commentcorrection/1931614-2785520, http://linkedlifedata.com/resource/pubmed/commentcorrection/1931614-2857419, http://linkedlifedata.com/resource/pubmed/commentcorrection/1931614-2884496, http://linkedlifedata.com/resource/pubmed/commentcorrection/1931614-3006036, http://linkedlifedata.com/resource/pubmed/commentcorrection/1931614-3007558, http://linkedlifedata.com/resource/pubmed/commentcorrection/1931614-3224082, http://linkedlifedata.com/resource/pubmed/commentcorrection/1931614-3291943, http://linkedlifedata.com/resource/pubmed/commentcorrection/1931614-3338667, http://linkedlifedata.com/resource/pubmed/commentcorrection/1931614-3499860, http://linkedlifedata.com/resource/pubmed/commentcorrection/1931614-6323517, http://linkedlifedata.com/resource/pubmed/commentcorrection/1931614-6331648, http://linkedlifedata.com/resource/pubmed/commentcorrection/1931614-6722773
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
907-10
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Epidermal growth factor receptors (EGFR) in human ovarian cancer.
pubmed:affiliation
Department of Biochemistry, Glasgow University, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't