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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-3-3
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pubmed:abstractText |
In Caenorhabditis elegans, the domains of Hox gene expression are controlled by the novel global regulatory gene sop-2. We identified a region located 3' of the Hox gene egl-5 that promotes ectopic expression of an egl-5 reporter gene in a sop-2 mutant. SOP-2 could directly block positive regulatory factors acting in this region, or it could block their expression. We identified three possible miRNA binding sites within the egl-5 3' untranslated region (UTR). Cognate microRNAs are expressed in relevant tissues and can block egl-5 expression when expressed from a transgene. Mutation of the putative binding sites in the egl-5 3'UTR resulted in a modest degree of misexpression of a minimal egl-5 reporter gene, suggesting that microRNAs may contribute to the tight restriction of egl-5 expression to particular cell lineages.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-10049576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-11962590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-12526742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-12758123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-12791274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-15081363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-15105502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-15200961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-15343333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-15581880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-15741313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-16116652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-16501168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-16914306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-17008523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-17185323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-17215367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-17320510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-18023351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-18199580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-18245856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-18668037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-1879361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-1935914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-4366476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-7409314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-7956833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-8202383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19235721-838129
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3' Untranslated Regions,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Egl-5 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MicroRNAs,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sop-2 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1058-8388
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2009 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
238
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
595-603
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:19235721-3' Untranslated Regions,
pubmed-meshheading:19235721-Animals,
pubmed-meshheading:19235721-Base Sequence,
pubmed-meshheading:19235721-Binding Sites,
pubmed-meshheading:19235721-Caenorhabditis elegans,
pubmed-meshheading:19235721-Caenorhabditis elegans Proteins,
pubmed-meshheading:19235721-Conserved Sequence,
pubmed-meshheading:19235721-DNA,
pubmed-meshheading:19235721-Gene Expression Regulation, Developmental,
pubmed-meshheading:19235721-Genes, Reporter,
pubmed-meshheading:19235721-Homeodomain Proteins,
pubmed-meshheading:19235721-Larva,
pubmed-meshheading:19235721-MicroRNAs,
pubmed-meshheading:19235721-Molecular Sequence Data,
pubmed-meshheading:19235721-Mutation,
pubmed-meshheading:19235721-Repressor Proteins,
pubmed-meshheading:19235721-Sequence Alignment,
pubmed-meshheading:19235721-Sexual Development,
pubmed-meshheading:19235721-Transcription Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Regulation of the Caenorhabditis elegans posterior Hox gene egl-5 by microRNA and the polycomb-like gene sop-2.
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pubmed:affiliation |
Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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