Source:http://linkedlifedata.com/resource/pubmed/id/19208035
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2009-2-11
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| pubmed:abstractText |
Aim: The effect of dietary cholesterol on plasma cholesterol concentrations varies widely among individuals. Recent studies suggest that the synthesis of oxysterols is up-regulated when tissue cholesterol is saturated. The present study was undertaken to test the hypothesis that a serum high concentration of 27-hydroxycholesterol, one of the oxysterols, reflects positive cholesterol balance in the body and predicts intolerance to a high-cholesterol diet. Methods: In 30 subjects, 750 mg/day of cholesterol was added for 4 weeks to the ordinary diet. Blood samples were collected at the start and finish of the supplementation. Serum sterol and oxysterol concentrations were measured by high-resolution GC-MS. Results: A receiver operating characteristic curve was drawn and the cutoff point (80 ng/mg cholesterol) was chosen to maximize sensitivity (81.3%) and specificity (64.3%) for predicting a positive change of LDL cholesterol concentration after cholesterol loading. Subjects with higher serum 27-hydroxycholesterol concentrations (>/= 80 ng/mg cholesterol) showed significantly (P < 0.05) high values for the change of LDL cholesterol concentration (+7.4 +/- 3.4%, mean +/- SEM, n = 17) compared with those with lower 27-hydroxycholesterol levels (-5.3 +/- 2.7%, n = 13). Conclusions: In subjects with high serum 27-hydroxycholesterol concentrations were unable to adapt to a high-cholesterol diet. The concentration of serum 27-hydroxycholesterol appears to reflect cholesterol saturation in the body and predicts to some extent a responsiveness to dietary cholesterol.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1386-6346
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
39
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
149-56
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| pubmed:year |
2009
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| pubmed:articleTitle |
Serum concentration of 27-hydroxycholesterol predicts the effects of high-cholesterol diet on plasma LDL cholesterol level.
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| pubmed:affiliation |
Department of Gastroenterology, Tokyo Medical University, Japan.
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| pubmed:publicationType |
Journal Article
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