Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-4-20
pubmed:abstractText
Increased protein synthesis is regulated, in part, by two eukaryotic translation initiation factors (eIFs): eIF4E and eIF2alpha. One or both of these factors are often overexpressed in several types of cancer cells; however, no data are available at present regarding eIF4E and eIF2alpha levels in brain tumors. In this study, we analyzed the expression, subcellular localization and phosphorylation states of eIF4E and eIF2alpha in 64 brain tumors (26 meningiomas, 16 oligodendroglial tumors, and 22 astrocytomas) and investigated the correlation with the expression of MIB-1, p53, and cyclin D1 proteins as well. There are significant differences in the phosphorylated eIF4E levels between the tumors studied, being the highest in meningiomas and the lowest in the oligodendroglial tumors. Relative to subcellular localization, eIF4E is frequently found in the nucleus of the oligodendroglial tumors and rarely in the same compartment of the meningiomas, whereas eIF2alpha showed an inverse pattern. Finally, cyclin D1 levels directly correlate with the phosphorylation status of both factors. The different expression, phosphorylation, or/and subcellular distribution of eIF2alpha and eIF4E within the brain types of tumors studied could indicate that different pathways are activated for promoting cell cycle proliferation, for instance, leading to increased cyclin D1 expression.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-10216939, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-10216945, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-10393856, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-10666371, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-10785360, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-10841309, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-10926326, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-11023817, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-11106749, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-11596034, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-11909525, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-11963652, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-12186496, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-12423333, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-12483527, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-1382315, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-15094768, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-15094773, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-15127288, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-15144396, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-15277680, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-15331580, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-15459663, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-15574771, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-15749420, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-15803138, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-15837800, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-15894932, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-15961768, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-17240151, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-17245113, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-17284108, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-17572691, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-17828301, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-18055695, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-18256539, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-18379871, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-7954824, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-8504413, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-8577715, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-8813130, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-8875465, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-9034372, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-942051, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-9498046, http://linkedlifedata.com/resource/pubmed/commentcorrection/19188486-9821169
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1554
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
503-12
pubmed:dateRevised
2010-9-22
pubmed:meshHeading
pubmed:year
2009
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