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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-2-9
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pubmed:abstractText |
Dependences on addictive substances are substantially-heritable complex disorders whose molecular genetic bases have been partially elucidated by studies that have largely focused on research volunteers, including those recruited in Baltimore. Maryland. Subjects recruited from the Baltimore site of the Epidemiological Catchment Area (ECA) study provide a potentially-useful comparison group for possible confounding features that might arise from selecting research volunteer samples of substance dependent and control individuals. We now report novel SNP (single nucleotide polymorphism) genome wide association (GWA) results for vulnerability to substance dependence in ECA participants, who were initially ascertained as members of a probability sample from Baltimore, and compare the results to those from ethnically-matched Baltimore research volunteers.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19094236-10207642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19094236-10402507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19094236-10491242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19094236-10711906,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19094236-9875838
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2350
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19094236-Alleles,
pubmed-meshheading:19094236-Baltimore,
pubmed-meshheading:19094236-Case-Control Studies,
pubmed-meshheading:19094236-European Continental Ancestry Group,
pubmed-meshheading:19094236-Female,
pubmed-meshheading:19094236-Gene Frequency,
pubmed-meshheading:19094236-Genome, Human,
pubmed-meshheading:19094236-Genome-Wide Association Study,
pubmed-meshheading:19094236-Humans,
pubmed-meshheading:19094236-Male,
pubmed-meshheading:19094236-Polymorphism, Single Nucleotide,
pubmed-meshheading:19094236-Substance-Related Disorders
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pubmed:year |
2008
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pubmed:articleTitle |
Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples.
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pubmed:affiliation |
Molecular Neurobiology Branch, NIH-IRP (NIDA), Suite 3510, 333 Cassell Drive Baltimore, Maryland 21224, USA. johnsoncat@intra.nida.nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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