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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-4-27
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pubmed:abstractText |
Expression of the principal initiator of coagulation, tissue factor (TF), by colorectal cancer (CRC) cells is involved in tumoral angiogenesis and metastasis progression, after binding of factor VIIa (FVIIa) to TF and generation of TF-FVIIa activity. We thus hypothesized that inhibition of the TF pathway by active site-blocked FVIIa (FFR-FVIIa) may prevent the development of hepatic metastasis in CRC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1095-8673
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pubmed:author |
pubmed-author:ChambonJean PierreJP,
pubmed-author:CorseauxDelphineD,
pubmed-author:GrimonprezAlexandreA,
pubmed-author:HebbarMohamedM,
pubmed-author:JudeBrigitteB,
pubmed-author:MouquetFredericF,
pubmed-author:NunesBertrandB,
pubmed-author:PetersenLars CLC,
pubmed-author:PruvotFrançois RenéFR,
pubmed-author:SusenSophieS,
pubmed-author:UngAlexandreA,
pubmed-author:ZerbibPhilippeP
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
153
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
239-45
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pubmed:meshHeading |
pubmed-meshheading:19062044-Animals,
pubmed-meshheading:19062044-Carcinoma,
pubmed-meshheading:19062044-Cell Line, Tumor,
pubmed-meshheading:19062044-Colorectal Neoplasms,
pubmed-meshheading:19062044-Factor VIIa,
pubmed-meshheading:19062044-Liver Neoplasms,
pubmed-meshheading:19062044-Male,
pubmed-meshheading:19062044-Neoplasm Metastasis,
pubmed-meshheading:19062044-Neoplasms, Experimental,
pubmed-meshheading:19062044-Rats,
pubmed-meshheading:19062044-Thromboplastin
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pubmed:year |
2009
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pubmed:articleTitle |
Inhibition of tissue factor-factor VIIa proteolytic activity blunts hepatic metastasis in colorectal cancer.
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pubmed:affiliation |
Inserm ERI-9, Faculté de Médecine Lille, France; Université de Lille 2, EA2693, Lille, France. p-zerbib@chru-lille.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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