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pubmed-article:18981300pubmed:abstractTextAlteration of the circadian rhythm and increased vascular senescence are linked to cardiovascular disease. Per2, a circadian gene, is known to regulate endothelium-dependent vasomotion. However, the mechanism by which Per2 affects endothelial function is unknown. We hypothesize that endothelial dysfunction in Per2 mutant (Per2(m/m)) mice is mediated in part by increased vascular senescence and impaired endothelial progenitor cell (EPC) function.lld:pubmed
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pubmed-article:18981300pubmed:authorpubmed-author:LiaoJames KJKlld:pubmed
pubmed-article:18981300pubmed:authorpubmed-author:WenMing-Shien...lld:pubmed
pubmed-article:18981300pubmed:authorpubmed-author:WangHong-WeiH...lld:pubmed
pubmed-article:18981300pubmed:authorpubmed-author:LiYuxinYlld:pubmed
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pubmed-article:18981300pubmed:authorpubmed-author:LinFun-ChungF...lld:pubmed
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