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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-10-14
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pubmed:abstractText |
The typical Western diet is not balanced in methyl nutrients that regulate the level of the methyl donor S-adenosylmethionine (SAM) and its derivative metabolite S-adenosylhomocysteine (SAH), which in turn may control the activity of certain methyltransferases. Feeding rodents with amino acid defined and methyl-imbalanced diet decreases hepatic SAM and causes liver cancers. RIZ1 (PRDM2 or KMT8) is a tumor suppressor and functions in transcriptional repression by methylating histone H3 lysine 9.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-11320206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-11465493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-11544182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-12189389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-12553907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-14633678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-15485804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-16079837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-17289570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-18082620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-3459914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-6317218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-6721844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-6872150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-7017215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-7538672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-8692960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-9006946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18852888-9632640
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e3390
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18852888-Animals,
pubmed-meshheading:18852888-DNA-Binding Proteins,
pubmed-meshheading:18852888-Diet,
pubmed-meshheading:18852888-Food,
pubmed-meshheading:18852888-Gene Expression Regulation,
pubmed-meshheading:18852888-Histone-Lysine N-Methyltransferase,
pubmed-meshheading:18852888-Methionine,
pubmed-meshheading:18852888-Methylation,
pubmed-meshheading:18852888-Mice,
pubmed-meshheading:18852888-Mice, Knockout,
pubmed-meshheading:18852888-Neoplasms,
pubmed-meshheading:18852888-Nuclear Proteins,
pubmed-meshheading:18852888-S-Adenosylmethionine,
pubmed-meshheading:18852888-Transcription Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Requirement of RIZ1 for cancer prevention by methyl-balanced diet.
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pubmed:affiliation |
Cancer Research Center, The Burnham Institute for Medical Research, La Jolla, California, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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