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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-10-9
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pubmed:abstractText |
Potassium countercurrent through the SR K+ channel plays an important role in Ca2+ release from the SR. To see if Ca2+ regulates the channel, we incorporated canine cardiac SR K+ channel into lipid bilayers. Calcium ions present in either the SR lumenal (trans) or cytoplasmic (cis) side blocked the cardiac SR K+ channel in a voltage-dependent manner. When Ca2+ was present on both sides, however, the block appeared to be voltage independent. A two-binding site model of blockade by an impermeant divalent cation (Ca2+) can explain this apparent contradiction. Estimates of SR Ca2+ concentration suggest that under physiological conditions the cardiac SR K+ channel is partially blocked by Ca2+ ions present in the lumen of the SR. The reduction in lumenal [Ca2+] during Ca2+ release could increase K+ conductance.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-13441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-2184764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-2301604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-2412606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-2420192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-2448641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-2463249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-2725677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-2794967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-2915210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-2930823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-427104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-4541078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-6148425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-6255061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-6255062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-6255336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-6284862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-6303204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-6312285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-6346892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-650672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-6698971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-6716284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-6752197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1883938-7085644
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-3495
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
198-203
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1883938-Animals,
pubmed-meshheading:1883938-Calcium,
pubmed-meshheading:1883938-Cytoplasm,
pubmed-meshheading:1883938-Dogs,
pubmed-meshheading:1883938-Heart,
pubmed-meshheading:1883938-Lipid Bilayers,
pubmed-meshheading:1883938-Mathematics,
pubmed-meshheading:1883938-Membrane Potentials,
pubmed-meshheading:1883938-Models, Biological,
pubmed-meshheading:1883938-Potassium Channels,
pubmed-meshheading:1883938-Sarcoplasmic Reticulum
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pubmed:year |
1991
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pubmed:articleTitle |
Blockade of cardiac sarcoplasmic reticulum K+ channel by Ca2+: two-binding-site model of blockade.
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pubmed:affiliation |
Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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