Linked Life Data

18667610

Source:http://linkedlifedata.com/resource/pubmed/id/18667610

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
31
pubmed:dateCreated
2008-7-31
pubmed:abstractText
Electrophysiological data measured by electroencephalography and magnetoencephalography (MEG) are widely used to investigate human brain activity in various cognitive tasks. This is typically done by characterizing event-related potentials/fields or modulations of oscillatory activity (e.g., event-related synchronization) in response to cognitively relevant stimuli. Here, we provide a link between the two phenomena. An essential component of our theory is that peaks and troughs of oscillatory activity fluctuate asymmetrically; e.g., peaks are more strongly modulated than troughs in response to stimuli. As a consequence, oscillatory brain activity will not "average out" when multiple trials are averaged. Using MEG, we demonstrate that such asymmetric amplitude fluctuations of the oscillatory alpha rhythm explain the generation of slow event-related fields. Furthermore, we provide a physiological explanation for the observed asymmetric amplitude fluctuations. In particular, slow event-related components are modulated by a wide range of cognitive tasks. Hence, our findings provide new insight into the physiological basis of cognitive modulation in event-related brain activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
30
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7781-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Asymmetric amplitude modulations of brain oscillations generate slow evoked responses.
pubmed:affiliation
F. C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, NL-6500 HB Nijmegen, The Netherlands.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't