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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
2008-11-27
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|
pubmed:abstractText |
The Kindler syndrome (KS) protein kindlin-1 is a member of a protein complex that links cortical actin to integrins on the surface of basal keratinocytes. Loss of kindlin-1 leads to abnormalities of cell adhesion and motility, and to skin blistering and progressive poikiloderma as clinical symptoms.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Nov
|
|
pubmed:issn |
1365-2133
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
159
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1192-6
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pubmed:meshHeading |
pubmed-meshheading:18652585-Adult,
pubmed-meshheading:18652585-Cell Adhesion,
pubmed-meshheading:18652585-Exons,
pubmed-meshheading:18652585-Frameshift Mutation,
pubmed-meshheading:18652585-Humans,
pubmed-meshheading:18652585-Immunoblotting,
pubmed-meshheading:18652585-Immunohistochemistry,
pubmed-meshheading:18652585-Keratinocytes,
pubmed-meshheading:18652585-Male,
pubmed-meshheading:18652585-Membrane Proteins,
pubmed-meshheading:18652585-Neoplasm Proteins,
pubmed-meshheading:18652585-Polymerase Chain Reaction,
pubmed-meshheading:18652585-Skin Diseases, Genetic
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pubmed:year |
2008
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|
pubmed:articleTitle |
C-terminally truncated kindlin-1 leads to abnormal adhesion and migration of keratinocytes.
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|
pubmed:affiliation |
Department of Dermatology, University Medical Center Freiburg, Hauptstr. 7, 79104 Freiburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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