| pubmed-article:18554903 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18554903 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:18554903 | lifeskim:mentions | umls-concept:C0243126 | lld:lifeskim |
| pubmed-article:18554903 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:18554903 | lifeskim:mentions | umls-concept:C2697525 | lld:lifeskim |
| pubmed-article:18554903 | lifeskim:mentions | umls-concept:C2606387 | lld:lifeskim |
| pubmed-article:18554903 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:18554903 | pubmed:dateCreated | 2008-7-21 | lld:pubmed |
| pubmed-article:18554903 | pubmed:abstractText | The first enantioselective synthesis of (D)-2-tert-butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid 3 was achieved. The incorporation of the titled compound into growth hormone secretagogue (GHS) compounds resulted in new analogs 10 and 16, both of which had significantly increased in vitro potency. The compound 10 also showed improved in vivo efficacy as well as pharmacokinetic properties in rat models. | lld:pubmed |
| pubmed-article:18554903 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18554903 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18554903 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18554903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18554903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18554903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18554903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18554903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18554903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18554903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18554903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18554903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18554903 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18554903 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18554903 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:18554903 | pubmed:author | pubmed-author:MeeSS | lld:pubmed |
| pubmed-article:18554903 | pubmed:author | pubmed-author:GordonDavidD | lld:pubmed |
| pubmed-article:18554903 | pubmed:author | pubmed-author:MurphyBrian... | lld:pubmed |
| pubmed-article:18554903 | pubmed:author | pubmed-author:HumphreysWill... | lld:pubmed |
| pubmed-article:18554903 | pubmed:author | pubmed-author:FlynnNeilN | lld:pubmed |
| pubmed-article:18554903 | pubmed:author | pubmed-author:EwingWilliam... | lld:pubmed |
| pubmed-article:18554903 | pubmed:author | pubmed-author:RoblJeffrey... | lld:pubmed |
| pubmed-article:18554903 | pubmed:author | pubmed-author:ZhangHongjian... | lld:pubmed |
| pubmed-article:18554903 | pubmed:author | pubmed-author:SeethalaRamak... | lld:pubmed |
| pubmed-article:18554903 | pubmed:author | pubmed-author:SlephPaulP | lld:pubmed |
| pubmed-article:18554903 | pubmed:author | pubmed-author:TinoJoseph... | lld:pubmed |
| pubmed-article:18554903 | pubmed:author | pubmed-author:YanMujingM | lld:pubmed |
| pubmed-article:18554903 | pubmed:author | pubmed-author:SlusarchykDor... | lld:pubmed |
| pubmed-article:18554903 | pubmed:author | pubmed-author:ChenStephanie... | lld:pubmed |
| pubmed-article:18554903 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18554903 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18554903 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:18554903 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18554903 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18554903 | pubmed:pagination | 4072-4 | lld:pubmed |
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| pubmed-article:18554903 | pubmed:meshHeading | pubmed-meshheading:18554903... | lld:pubmed |
| pubmed-article:18554903 | pubmed:meshHeading | pubmed-meshheading:18554903... | lld:pubmed |
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| pubmed-article:18554903 | pubmed:meshHeading | pubmed-meshheading:18554903... | lld:pubmed |
| pubmed-article:18554903 | pubmed:meshHeading | pubmed-meshheading:18554903... | lld:pubmed |
| pubmed-article:18554903 | pubmed:meshHeading | pubmed-meshheading:18554903... | lld:pubmed |
| pubmed-article:18554903 | pubmed:meshHeading | pubmed-meshheading:18554903... | lld:pubmed |
| pubmed-article:18554903 | pubmed:meshHeading | pubmed-meshheading:18554903... | lld:pubmed |
| pubmed-article:18554903 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18554903 | pubmed:articleTitle | (D)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: synthesis and incorporation into the growth hormone secretagogues. | lld:pubmed |
| pubmed-article:18554903 | pubmed:affiliation | Discovery Chemistry, Bristol Myers Squibb, Princeton, NJ 08543, USA. jun.li@bms.com | lld:pubmed |
| pubmed-article:18554903 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:18554903 | lld:chembl |
