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rdf:type |
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lifeskim:mentions |
umls-concept:C0001492,
umls-concept:C0013138,
umls-concept:C0024660,
umls-concept:C0033684,
umls-concept:C0205169,
umls-concept:C0597357,
umls-concept:C0887847,
umls-concept:C1366550,
umls-concept:C1515877,
umls-concept:C1704675,
umls-concept:C1879547
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pubmed:issue |
5
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pubmed:dateCreated |
1991-4-11
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pubmed:abstractText |
Heterotrimeric guanine nucleotide binding proteins (G proteins) transduce signals from cell-surface receptors to intracellular effector proteins. Two forms of stimulatory G protein (Gs) alpha-like subunit have been described in Drosophila melanogaster. To examine the function of these subunits we have used vaccinia virus vectors to express both proteins in cyc- cells, a murine S49 cell line deficient for Gs alpha activity. Receptor-independent activation of each Drosophila Gs alpha has demonstrated that both forms are capable of activating mammalian adenylyl cyclase and thus have the activity expected of stimulatory G proteins. However, the Drosophila Gs alpha subunits interact poorly with mammalian Gs-coupled receptors. These observations have helped to identify a region of high variability in Gs alpha proteins that may be important for receptor interactions.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2105931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2106072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2108229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2440344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2448879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2494654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2498884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2499043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2510151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2549064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2549065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2549426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2820999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2826123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2827032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-2899356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-3012250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-3092218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-3103658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-3113327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-3132454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-3148932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-3304147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-3316207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-3822832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-3839937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-3843705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-3881765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-3898365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-3908095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-4032536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-6092966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-6142883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-6203340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-6259507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-6289322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-6296147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-6396323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-6582062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-6892111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848015-6935665
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1898-902
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1848015-Animals,
pubmed-meshheading:1848015-Drosophila,
pubmed-meshheading:1848015-Vaccinia virus,
pubmed-meshheading:1848015-Kinetics,
pubmed-meshheading:1848015-Base Sequence,
pubmed-meshheading:1848015-Amino Acid Sequence,
pubmed-meshheading:1848015-Macromolecular Substances,
pubmed-meshheading:1848015-Cell Line,
pubmed-meshheading:1848015-Enzyme Activation,
pubmed-meshheading:1848015-Molecular Sequence Data,
pubmed-meshheading:1848015-Adenylate Cyclase,
pubmed-meshheading:1848015-Receptors, Cell Surface,
pubmed-meshheading:1848015-Cloning, Molecular,
pubmed-meshheading:1848015-Signal Transduction,
pubmed-meshheading:1848015-Restriction Mapping,
pubmed-meshheading:1848015-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1848015-Cholera Toxin,
pubmed-meshheading:1848015-Recombinant Proteins,
pubmed-meshheading:1848015-Genetic Vectors
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